ZnO nanowire-FET for charge-based sensing of protein biomolecules

N. M.J. Ditshego, N. A.B. Ghazali, M. Ebert, K. Sun, I. Zeimpekis, P. Ashburn, M. R.R. De Planque, H. M.H. Chong

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Citations (Scopus)

Abstract

Top-down method was used to fabricate zinc oxide (ZnO) nano wire field effect transistor (NWFET) biosensor. The nanosensor was used to measure the electrical characteristics of lysozyme (LYSO) and bovine serum albumin (BSA) protein solutions in phosphate buffered saline (PBS). The LYSO and BSA proteins are oppositely charged at measurement pH of 7.4. Subthreshold voltage shift of 340 mV and 700 mV due to surface charge effect on the device channel is obtained for the LYSO and BSA solutions respectively. A NWFET sensitivity of 72 % is achieved for the LYSO proteins while the BSA proteins resulted in a sensitivity of 98%.

Original languageEnglish
Title of host publicationIEEE-NANO 2015 - 15th International Conference on Nanotechnology
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages801-804
Number of pages4
ISBN (Electronic)9781467381550
DOIs
Publication statusPublished - Jan 1 2015
Event15th IEEE International Conference on Nanotechnology, IEEE-NANO 2015 - Rome, Italy
Duration: Jul 27 2015Jul 30 2015

Other

Other15th IEEE International Conference on Nanotechnology, IEEE-NANO 2015
CountryItaly
CityRome
Period7/27/157/30/15

Fingerprint

Zinc Oxide
Biomolecules
Muramidase
Bovine Serum Albumin
Field effect transistors
Zinc oxide
Nanowires
Enzymes
Proteins
Wire
Nanosensors
Surface charge
Biosensors
Phosphates
Electric potential

All Science Journal Classification (ASJC) codes

  • Process Chemistry and Technology
  • Electrical and Electronic Engineering
  • Ceramics and Composites
  • Electronic, Optical and Magnetic Materials
  • Surfaces, Coatings and Films

Cite this

Ditshego, N. M. J., Ghazali, N. A. B., Ebert, M., Sun, K., Zeimpekis, I., Ashburn, P., ... Chong, H. M. H. (2015). ZnO nanowire-FET for charge-based sensing of protein biomolecules. In IEEE-NANO 2015 - 15th International Conference on Nanotechnology (pp. 801-804). [7388733] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/NANO.2015.7388733
Ditshego, N. M.J. ; Ghazali, N. A.B. ; Ebert, M. ; Sun, K. ; Zeimpekis, I. ; Ashburn, P. ; De Planque, M. R.R. ; Chong, H. M.H. / ZnO nanowire-FET for charge-based sensing of protein biomolecules. IEEE-NANO 2015 - 15th International Conference on Nanotechnology. Institute of Electrical and Electronics Engineers Inc., 2015. pp. 801-804
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abstract = "Top-down method was used to fabricate zinc oxide (ZnO) nano wire field effect transistor (NWFET) biosensor. The nanosensor was used to measure the electrical characteristics of lysozyme (LYSO) and bovine serum albumin (BSA) protein solutions in phosphate buffered saline (PBS). The LYSO and BSA proteins are oppositely charged at measurement pH of 7.4. Subthreshold voltage shift of 340 mV and 700 mV due to surface charge effect on the device channel is obtained for the LYSO and BSA solutions respectively. A NWFET sensitivity of 72 {\%} is achieved for the LYSO proteins while the BSA proteins resulted in a sensitivity of 98{\%}.",
author = "Ditshego, {N. M.J.} and Ghazali, {N. A.B.} and M. Ebert and K. Sun and I. Zeimpekis and P. Ashburn and {De Planque}, {M. R.R.} and Chong, {H. M.H.}",
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Ditshego, NMJ, Ghazali, NAB, Ebert, M, Sun, K, Zeimpekis, I, Ashburn, P, De Planque, MRR & Chong, HMH 2015, ZnO nanowire-FET for charge-based sensing of protein biomolecules. in IEEE-NANO 2015 - 15th International Conference on Nanotechnology., 7388733, Institute of Electrical and Electronics Engineers Inc., pp. 801-804, 15th IEEE International Conference on Nanotechnology, IEEE-NANO 2015, Rome, Italy, 7/27/15. https://doi.org/10.1109/NANO.2015.7388733

ZnO nanowire-FET for charge-based sensing of protein biomolecules. / Ditshego, N. M.J.; Ghazali, N. A.B.; Ebert, M.; Sun, K.; Zeimpekis, I.; Ashburn, P.; De Planque, M. R.R.; Chong, H. M.H.

IEEE-NANO 2015 - 15th International Conference on Nanotechnology. Institute of Electrical and Electronics Engineers Inc., 2015. p. 801-804 7388733.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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AU - Ditshego, N. M.J.

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N2 - Top-down method was used to fabricate zinc oxide (ZnO) nano wire field effect transistor (NWFET) biosensor. The nanosensor was used to measure the electrical characteristics of lysozyme (LYSO) and bovine serum albumin (BSA) protein solutions in phosphate buffered saline (PBS). The LYSO and BSA proteins are oppositely charged at measurement pH of 7.4. Subthreshold voltage shift of 340 mV and 700 mV due to surface charge effect on the device channel is obtained for the LYSO and BSA solutions respectively. A NWFET sensitivity of 72 % is achieved for the LYSO proteins while the BSA proteins resulted in a sensitivity of 98%.

AB - Top-down method was used to fabricate zinc oxide (ZnO) nano wire field effect transistor (NWFET) biosensor. The nanosensor was used to measure the electrical characteristics of lysozyme (LYSO) and bovine serum albumin (BSA) protein solutions in phosphate buffered saline (PBS). The LYSO and BSA proteins are oppositely charged at measurement pH of 7.4. Subthreshold voltage shift of 340 mV and 700 mV due to surface charge effect on the device channel is obtained for the LYSO and BSA solutions respectively. A NWFET sensitivity of 72 % is achieved for the LYSO proteins while the BSA proteins resulted in a sensitivity of 98%.

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Ditshego NMJ, Ghazali NAB, Ebert M, Sun K, Zeimpekis I, Ashburn P et al. ZnO nanowire-FET for charge-based sensing of protein biomolecules. In IEEE-NANO 2015 - 15th International Conference on Nanotechnology. Institute of Electrical and Electronics Engineers Inc. 2015. p. 801-804. 7388733 https://doi.org/10.1109/NANO.2015.7388733