Abstract
Multiplexed sensors enable simultaneous detection of disease biomarkers and environmental contaminants using a single test. Test results feature multiple signals, which if unclear, can result in misdiagnosis. This work studies the phenomenon of weakening signal intensities on multiplexed lateral flow tests. Results indicate that physical analyte entrapment has minimal impact on this phenomenon, which is influenced more, by the quantity of analyte in the sample and the positioning of the test line. Recommendations are made on the maximum number of test lines that should be employed to avoid reduced signal intensities, and the benefits of paper based microfluidics are discussed.
| Original language | English |
|---|---|
| Title of host publication | MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences |
| Publisher | Chemical and Biological Microsystems Society |
| Pages | 1640-1642 |
| Number of pages | 3 |
| ISBN (Electronic) | 9780979806483 |
| Publication status | Published - Jan 1 2015 |
| Event | 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015 - Gyeongju, Korea, Republic of Duration: Oct 25 2015 → Oct 29 2015 |
Other
| Other | 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015 |
|---|---|
| Country | Korea, Republic of |
| City | Gyeongju |
| Period | 10/25/15 → 10/29/15 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Control and Systems Engineering
Cite this
}
Understanding the functionality of multiplexed sensors in order to aid design and enhance performance. / Moodley, K.; Land, K. J.; Muzenda, E.
MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society, 2015. p. 1640-1642.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
TY - GEN
T1 - Understanding the functionality of multiplexed sensors in order to aid design and enhance performance
AU - Moodley, K.
AU - Land, K. J.
AU - Muzenda, E.
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Multiplexed sensors enable simultaneous detection of disease biomarkers and environmental contaminants using a single test. Test results feature multiple signals, which if unclear, can result in misdiagnosis. This work studies the phenomenon of weakening signal intensities on multiplexed lateral flow tests. Results indicate that physical analyte entrapment has minimal impact on this phenomenon, which is influenced more, by the quantity of analyte in the sample and the positioning of the test line. Recommendations are made on the maximum number of test lines that should be employed to avoid reduced signal intensities, and the benefits of paper based microfluidics are discussed.
AB - Multiplexed sensors enable simultaneous detection of disease biomarkers and environmental contaminants using a single test. Test results feature multiple signals, which if unclear, can result in misdiagnosis. This work studies the phenomenon of weakening signal intensities on multiplexed lateral flow tests. Results indicate that physical analyte entrapment has minimal impact on this phenomenon, which is influenced more, by the quantity of analyte in the sample and the positioning of the test line. Recommendations are made on the maximum number of test lines that should be employed to avoid reduced signal intensities, and the benefits of paper based microfluidics are discussed.
UR - http://www.scopus.com/inward/record.url?scp=84983314871&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84983314871&partnerID=8YFLogxK
M3 - Conference contribution
SP - 1640
EP - 1642
BT - MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PB - Chemical and Biological Microsystems Society
ER -