Umbelliferone: Sources, chemistry and bioactivities review

Research output: Contribution to journalArticle

Abstract

Umbelliferone is a 7-hydroxycoumarin that is a pharmacologically active agent. It is widely distributed within the Rutaceae and Apiaceae (Umbelliferae) families and is efficiently extracted using methanol. Umbelliferone is a fluorescing compound used as a sunscreen agent. It is synthesized using the Pechmann condensation reaction of resorcinol and formyl acetic acid. Biosynthetically it is synthesized using the phenylpropanoid pathway. Umbelliferone is a synthon for other coumarins and heterocycles with improved biological activities. In the Literature modest antibacterial and antifungal activities are reported with MIC values of 500–1000μg/mL, but exhibited good E. coli anti-biofilm formation. Umbelliferone shows good inhibitions of DPPH, hydroxyl, superoxide anion and ABTS radicals. Other reported activities are anti-inflammatory, anti-hyperglycaemic, molluscicidal and anti-tumor activities.
Original languageEnglish
Pages (from-to)223-232
Number of pages10
JournalBulletin of Faculty of Pharmacy, Cairo University
Volume55
Issue number2
DOIs
Publication statusPublished - 2017

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7-hydroxycoumarin
Bioactivity
Apiaceae
Rutaceae
Sun hoods
Coumarins
Sunscreening Agents
Condensation reactions
Biofilms
Superoxides
Acetic Acid
Hydroxyl Radical
Escherichia coli
Methanol
Tumors
Anti-Inflammatory Agents

Cite this

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abstract = "Umbelliferone is a 7-hydroxycoumarin that is a pharmacologically active agent. It is widely distributed within the Rutaceae and Apiaceae (Umbelliferae) families and is efficiently extracted using methanol. Umbelliferone is a fluorescing compound used as a sunscreen agent. It is synthesized using the Pechmann condensation reaction of resorcinol and formyl acetic acid. Biosynthetically it is synthesized using the phenylpropanoid pathway. Umbelliferone is a synthon for other coumarins and heterocycles with improved biological activities. In the Literature modest antibacterial and antifungal activities are reported with MIC values of 500–1000μg/mL, but exhibited good E. coli anti-biofilm formation. Umbelliferone shows good inhibitions of DPPH, hydroxyl, superoxide anion and ABTS radicals. Other reported activities are anti-inflammatory, anti-hyperglycaemic, molluscicidal and anti-tumor activities.",
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Umbelliferone: Sources, chemistry and bioactivities review. / Mazimba, Ofentse.

In: Bulletin of Faculty of Pharmacy, Cairo University, Vol. 55, No. 2, 2017, p. 223-232.

Research output: Contribution to journalArticle

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