The effect of shape factor on the magnetic targeting in the permeable microvessel with two-phase casson fluid model

Sachin Shaw, P. V S N Murthy

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The present investigation deals with magnetic drug targeting in a microvessel of radius 5 m using two-phase fluid model. The microvessel is divided into the endothelial glycocalyx layer wherein the blood obeys Newtonian character and a core region wherein the blood obeys the non-Newtonian Casson fluid character. The carrier particles, bound with nanoparticles and drug molecules, are injected into the vascular system upstream from the malignant tissue and are captured at the tumor site using a local applied magnetic field near the tumor position. Brinkman model is used to characterize the permeable nature of the inner wall of the microvessel. The expressions for the fluidic force for the carrier particle traversing in the two-phase fluid in the microvessel and the magnetic force due to the external magnetic field are obtained. Several factors that influence the magnetic targeting of the carrier particles in the microvasculature, such as the size and shape of the carrier particle, the volume fraction of embedded magnetic nanoparticles, and the distance of separation of the magnet from the axis of the microvessel, are considered in the present problem. The system of coupled equations is solved to obtain the trajectories of the carrier particle in the noninvasive case.

Original languageEnglish
Article number041003
JournalJournal of Nanotechnology in Engineering and Medicine
Volume2
Issue number4
DOIs
Publication statusPublished - Nov 2011

Fingerprint

Microvessels
Fluids
Tumors
Blood
Magnetic fields
Nanoparticles
Fluidics
Magnetic Fields
Magnets
Volume fraction
Trajectories
Tissue
Glycocalyx
Molecules
Drug Delivery Systems
Pharmaceutical Preparations
Blood Vessels
Neoplasms

All Science Journal Classification (ASJC) codes

  • Electrical and Electronic Engineering
  • Materials Science(all)
  • Medicine(all)

Cite this

@article{a41bcf8094d64f7abc46da17ba614cc1,
title = "The effect of shape factor on the magnetic targeting in the permeable microvessel with two-phase casson fluid model",
abstract = "The present investigation deals with magnetic drug targeting in a microvessel of radius 5 m using two-phase fluid model. The microvessel is divided into the endothelial glycocalyx layer wherein the blood obeys Newtonian character and a core region wherein the blood obeys the non-Newtonian Casson fluid character. The carrier particles, bound with nanoparticles and drug molecules, are injected into the vascular system upstream from the malignant tissue and are captured at the tumor site using a local applied magnetic field near the tumor position. Brinkman model is used to characterize the permeable nature of the inner wall of the microvessel. The expressions for the fluidic force for the carrier particle traversing in the two-phase fluid in the microvessel and the magnetic force due to the external magnetic field are obtained. Several factors that influence the magnetic targeting of the carrier particles in the microvasculature, such as the size and shape of the carrier particle, the volume fraction of embedded magnetic nanoparticles, and the distance of separation of the magnet from the axis of the microvessel, are considered in the present problem. The system of coupled equations is solved to obtain the trajectories of the carrier particle in the noninvasive case.",
author = "Sachin Shaw and Murthy, {P. V S N}",
year = "2011",
month = "11",
doi = "10.1115/1.4005675",
language = "English",
volume = "2",
journal = "Journal of Nanotechnology in Engineering and Medicine",
issn = "1949-2944",
publisher = "American Society of Mechanical Engineers(ASME)",
number = "4",

}

TY - JOUR

T1 - The effect of shape factor on the magnetic targeting in the permeable microvessel with two-phase casson fluid model

AU - Shaw, Sachin

AU - Murthy, P. V S N

PY - 2011/11

Y1 - 2011/11

N2 - The present investigation deals with magnetic drug targeting in a microvessel of radius 5 m using two-phase fluid model. The microvessel is divided into the endothelial glycocalyx layer wherein the blood obeys Newtonian character and a core region wherein the blood obeys the non-Newtonian Casson fluid character. The carrier particles, bound with nanoparticles and drug molecules, are injected into the vascular system upstream from the malignant tissue and are captured at the tumor site using a local applied magnetic field near the tumor position. Brinkman model is used to characterize the permeable nature of the inner wall of the microvessel. The expressions for the fluidic force for the carrier particle traversing in the two-phase fluid in the microvessel and the magnetic force due to the external magnetic field are obtained. Several factors that influence the magnetic targeting of the carrier particles in the microvasculature, such as the size and shape of the carrier particle, the volume fraction of embedded magnetic nanoparticles, and the distance of separation of the magnet from the axis of the microvessel, are considered in the present problem. The system of coupled equations is solved to obtain the trajectories of the carrier particle in the noninvasive case.

AB - The present investigation deals with magnetic drug targeting in a microvessel of radius 5 m using two-phase fluid model. The microvessel is divided into the endothelial glycocalyx layer wherein the blood obeys Newtonian character and a core region wherein the blood obeys the non-Newtonian Casson fluid character. The carrier particles, bound with nanoparticles and drug molecules, are injected into the vascular system upstream from the malignant tissue and are captured at the tumor site using a local applied magnetic field near the tumor position. Brinkman model is used to characterize the permeable nature of the inner wall of the microvessel. The expressions for the fluidic force for the carrier particle traversing in the two-phase fluid in the microvessel and the magnetic force due to the external magnetic field are obtained. Several factors that influence the magnetic targeting of the carrier particles in the microvasculature, such as the size and shape of the carrier particle, the volume fraction of embedded magnetic nanoparticles, and the distance of separation of the magnet from the axis of the microvessel, are considered in the present problem. The system of coupled equations is solved to obtain the trajectories of the carrier particle in the noninvasive case.

UR - http://www.scopus.com/inward/record.url?scp=84859875086&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84859875086&partnerID=8YFLogxK

U2 - 10.1115/1.4005675

DO - 10.1115/1.4005675

M3 - Article

AN - SCOPUS:84859875086

VL - 2

JO - Journal of Nanotechnology in Engineering and Medicine

JF - Journal of Nanotechnology in Engineering and Medicine

SN - 1949-2944

IS - 4

M1 - 041003

ER -