Synthesis, characterization of gold (III) complexes and an in vitro evaluation of their cytotoxic properties

Haleden Chiririwa, Edison Muzenda

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    1 Citation (Scopus)

    Abstract

    Three tetradentate Schiff base ligands and gold (III) complexes have been synthesized by a 2:1 molar condensation of salicylaldehyde with ethylenediamine and o- phenylenediamine. The ligands are N,N'-bis (salicylaldehyde) ethylenediamine (1), N,N'-bis (salicylaldehyde) o- phenylenediamine (2) and N,N'-bis (salicylaldehyde)- dimethylbenzene-l,2-diamine. The prepared ligands and their complexes have been characterized by elemental analyses, melting points, infrared spectroscopy and 'H NMR. The spectral data of the ligands and their complexes are discussed in relation to structural changes due to complications. In vitro cytotoxic study results show that the gold complexes exhibit moderate activity and block the proliferation of WHCOl cells with an IC50 range of 19.02 - 45.27μM, and IC50 range of 10.03 - 68.54μM for the WHCO6 lines.

    Original languageEnglish
    Title of host publicationWorld Congress on Engineering, WCE 2014
    PublisherNewswood Limited
    Pages637-640
    Number of pages4
    Volume2
    ISBN (Electronic)9789881925374
    ISBN (Print)9789881925350
    Publication statusPublished - 2014
    EventWorld Congress on Engineering and Computer Science 2014, WCECS 2014 - San Francisco, United States
    Duration: Oct 22 2014Oct 24 2014

    Other

    OtherWorld Congress on Engineering and Computer Science 2014, WCECS 2014
    CountryUnited States
    CitySan Francisco
    Period10/22/1410/24/14

    Fingerprint

    Gold
    Ligands
    Melting point
    Condensation
    Infrared spectroscopy
    Nuclear magnetic resonance

    All Science Journal Classification (ASJC) codes

    • Computer Science (miscellaneous)

    Cite this

    Chiririwa, H., & Muzenda, E. (2014). Synthesis, characterization of gold (III) complexes and an in vitro evaluation of their cytotoxic properties. In World Congress on Engineering, WCE 2014 (Vol. 2, pp. 637-640). Newswood Limited.
    Chiririwa, Haleden ; Muzenda, Edison. / Synthesis, characterization of gold (III) complexes and an in vitro evaluation of their cytotoxic properties. World Congress on Engineering, WCE 2014. Vol. 2 Newswood Limited, 2014. pp. 637-640
    @inproceedings{45db7063c9e44dddaab8d8509bfca350,
    title = "Synthesis, characterization of gold (III) complexes and an in vitro evaluation of their cytotoxic properties",
    abstract = "Three tetradentate Schiff base ligands and gold (III) complexes have been synthesized by a 2:1 molar condensation of salicylaldehyde with ethylenediamine and o- phenylenediamine. The ligands are N,N'-bis (salicylaldehyde) ethylenediamine (1), N,N'-bis (salicylaldehyde) o- phenylenediamine (2) and N,N'-bis (salicylaldehyde)- dimethylbenzene-l,2-diamine. The prepared ligands and their complexes have been characterized by elemental analyses, melting points, infrared spectroscopy and 'H NMR. The spectral data of the ligands and their complexes are discussed in relation to structural changes due to complications. In vitro cytotoxic study results show that the gold complexes exhibit moderate activity and block the proliferation of WHCOl cells with an IC50 range of 19.02 - 45.27μM, and IC50 range of 10.03 - 68.54μM for the WHCO6 lines.",
    author = "Haleden Chiririwa and Edison Muzenda",
    year = "2014",
    language = "English",
    isbn = "9789881925350",
    volume = "2",
    pages = "637--640",
    booktitle = "World Congress on Engineering, WCE 2014",
    publisher = "Newswood Limited",

    }

    Chiririwa, H & Muzenda, E 2014, Synthesis, characterization of gold (III) complexes and an in vitro evaluation of their cytotoxic properties. in World Congress on Engineering, WCE 2014. vol. 2, Newswood Limited, pp. 637-640, World Congress on Engineering and Computer Science 2014, WCECS 2014, San Francisco, United States, 10/22/14.

    Synthesis, characterization of gold (III) complexes and an in vitro evaluation of their cytotoxic properties. / Chiririwa, Haleden; Muzenda, Edison.

    World Congress on Engineering, WCE 2014. Vol. 2 Newswood Limited, 2014. p. 637-640.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    TY - GEN

    T1 - Synthesis, characterization of gold (III) complexes and an in vitro evaluation of their cytotoxic properties

    AU - Chiririwa, Haleden

    AU - Muzenda, Edison

    PY - 2014

    Y1 - 2014

    N2 - Three tetradentate Schiff base ligands and gold (III) complexes have been synthesized by a 2:1 molar condensation of salicylaldehyde with ethylenediamine and o- phenylenediamine. The ligands are N,N'-bis (salicylaldehyde) ethylenediamine (1), N,N'-bis (salicylaldehyde) o- phenylenediamine (2) and N,N'-bis (salicylaldehyde)- dimethylbenzene-l,2-diamine. The prepared ligands and their complexes have been characterized by elemental analyses, melting points, infrared spectroscopy and 'H NMR. The spectral data of the ligands and their complexes are discussed in relation to structural changes due to complications. In vitro cytotoxic study results show that the gold complexes exhibit moderate activity and block the proliferation of WHCOl cells with an IC50 range of 19.02 - 45.27μM, and IC50 range of 10.03 - 68.54μM for the WHCO6 lines.

    AB - Three tetradentate Schiff base ligands and gold (III) complexes have been synthesized by a 2:1 molar condensation of salicylaldehyde with ethylenediamine and o- phenylenediamine. The ligands are N,N'-bis (salicylaldehyde) ethylenediamine (1), N,N'-bis (salicylaldehyde) o- phenylenediamine (2) and N,N'-bis (salicylaldehyde)- dimethylbenzene-l,2-diamine. The prepared ligands and their complexes have been characterized by elemental analyses, melting points, infrared spectroscopy and 'H NMR. The spectral data of the ligands and their complexes are discussed in relation to structural changes due to complications. In vitro cytotoxic study results show that the gold complexes exhibit moderate activity and block the proliferation of WHCOl cells with an IC50 range of 19.02 - 45.27μM, and IC50 range of 10.03 - 68.54μM for the WHCO6 lines.

    UR - http://www.scopus.com/inward/record.url?scp=84918547481&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=84918547481&partnerID=8YFLogxK

    M3 - Conference contribution

    SN - 9789881925350

    VL - 2

    SP - 637

    EP - 640

    BT - World Congress on Engineering, WCE 2014

    PB - Newswood Limited

    ER -

    Chiririwa H, Muzenda E. Synthesis, characterization of gold (III) complexes and an in vitro evaluation of their cytotoxic properties. In World Congress on Engineering, WCE 2014. Vol. 2. Newswood Limited. 2014. p. 637-640