Synthesis, characterization of gold (III) complexes and an in vitro evaluation of their cytotoxic properties

Haleden Chiririwa; Edison Muzenda

Synthesis, characterization of gold (III) complexes and an in vitro evaluation of their cytotoxic properties

Haleden Chiririwa, Edison Muzenda

Chemical, Materials & Metallurgical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

3 Citations (Scopus)

Abstract

Three tetradentate Schiff base ligands and gold (III) complexes have been synthesized by a 2:1 molar condensation of salicylaldehyde with ethylenediamine and o- phenylenediamine. The ligands are N,N'-bis (salicylaldehyde) ethylenediamine (1), N,N'-bis (salicylaldehyde) o- phenylenediamine (2) and N,N'-bis (salicylaldehyde)- dimethylbenzene-l,2-diamine. The prepared ligands and their complexes have been characterized by elemental analyses, melting points, infrared spectroscopy and 'H NMR. The spectral data of the ligands and their complexes are discussed in relation to structural changes due to complications. In vitro cytotoxic study results show that the gold complexes exhibit moderate activity and block the proliferation of WHCOl cells with an IC₅₀ range of 19.02 - 45.27μM, and IC₅₀ range of 10.03 - 68.54μM for the WHCO6 lines.

Original language	English
Title of host publication	World Congress on Engineering, WCE 2014
Publisher	Newswood Limited
Pages	637-640
Number of pages	4
Volume	2
ISBN (Electronic)	9789881925374
ISBN (Print)	9789881925350
Publication status	Published - 2014
Event	World Congress on Engineering and Computer Science 2014, WCECS 2014 - San Francisco, United States Duration: Oct 22 2014 → Oct 24 2014

Other

Other	World Congress on Engineering and Computer Science 2014, WCECS 2014
Country/Territory	United States
City	San Francisco
Period	10/22/14 → 10/24/14

All Science Journal Classification (ASJC) codes

Computer Science (miscellaneous)

Cite this

@inproceedings{45db7063c9e44dddaab8d8509bfca350,

title = "Synthesis, characterization of gold (III) complexes and an in vitro evaluation of their cytotoxic properties",

abstract = "Three tetradentate Schiff base ligands and gold (III) complexes have been synthesized by a 2:1 molar condensation of salicylaldehyde with ethylenediamine and o- phenylenediamine. The ligands are N,N'-bis (salicylaldehyde) ethylenediamine (1), N,N'-bis (salicylaldehyde) o- phenylenediamine (2) and N,N'-bis (salicylaldehyde)- dimethylbenzene-l,2-diamine. The prepared ligands and their complexes have been characterized by elemental analyses, melting points, infrared spectroscopy and 'H NMR. The spectral data of the ligands and their complexes are discussed in relation to structural changes due to complications. In vitro cytotoxic study results show that the gold complexes exhibit moderate activity and block the proliferation of WHCOl cells with an IC50 range of 19.02 - 45.27μM, and IC50 range of 10.03 - 68.54μM for the WHCO6 lines.",

author = "Haleden Chiririwa and Edison Muzenda",

year = "2014",

language = "English",

isbn = "9789881925350",

volume = "2",

pages = "637--640",

booktitle = "World Congress on Engineering, WCE 2014",

publisher = "Newswood Limited",

note = "World Congress on Engineering and Computer Science 2014, WCECS 2014 ; Conference date: 22-10-2014 Through 24-10-2014",

}

TY - GEN

T1 - Synthesis, characterization of gold (III) complexes and an in vitro evaluation of their cytotoxic properties

AU - Chiririwa, Haleden

AU - Muzenda, Edison

PY - 2014

Y1 - 2014

N2 - Three tetradentate Schiff base ligands and gold (III) complexes have been synthesized by a 2:1 molar condensation of salicylaldehyde with ethylenediamine and o- phenylenediamine. The ligands are N,N'-bis (salicylaldehyde) ethylenediamine (1), N,N'-bis (salicylaldehyde) o- phenylenediamine (2) and N,N'-bis (salicylaldehyde)- dimethylbenzene-l,2-diamine. The prepared ligands and their complexes have been characterized by elemental analyses, melting points, infrared spectroscopy and 'H NMR. The spectral data of the ligands and their complexes are discussed in relation to structural changes due to complications. In vitro cytotoxic study results show that the gold complexes exhibit moderate activity and block the proliferation of WHCOl cells with an IC50 range of 19.02 - 45.27μM, and IC50 range of 10.03 - 68.54μM for the WHCO6 lines.

AB - Three tetradentate Schiff base ligands and gold (III) complexes have been synthesized by a 2:1 molar condensation of salicylaldehyde with ethylenediamine and o- phenylenediamine. The ligands are N,N'-bis (salicylaldehyde) ethylenediamine (1), N,N'-bis (salicylaldehyde) o- phenylenediamine (2) and N,N'-bis (salicylaldehyde)- dimethylbenzene-l,2-diamine. The prepared ligands and their complexes have been characterized by elemental analyses, melting points, infrared spectroscopy and 'H NMR. The spectral data of the ligands and their complexes are discussed in relation to structural changes due to complications. In vitro cytotoxic study results show that the gold complexes exhibit moderate activity and block the proliferation of WHCOl cells with an IC50 range of 19.02 - 45.27μM, and IC50 range of 10.03 - 68.54μM for the WHCO6 lines.

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M3 - Conference contribution

AN - SCOPUS:84918547481

SN - 9789881925350

VL - 2

SP - 637

EP - 640

BT - World Congress on Engineering, WCE 2014

PB - Newswood Limited

T2 - World Congress on Engineering and Computer Science 2014, WCECS 2014

Y2 - 22 October 2014 through 24 October 2014

ER -

Synthesis, characterization of gold (III) complexes and an in vitro evaluation of their cytotoxic properties

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