Synthesis, characterization of gold (III) complexes and an in vitro evaluation of their cytotoxic properties

Haleden Chiririwa, Edison Muzenda

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Three tetradentate Schiff base ligands and gold (III) complexes have been synthesized by a 2:1 molar condensation of salicylaldehyde with ethylenediamine and o- phenylenediamine. The ligands are N,N'-bis (salicylaldehyde) ethylenediamine (1), N,N'-bis (salicylaldehyde) o- phenylenediamine (2) and N,N'-bis (salicylaldehyde)- dimethylbenzene-l,2-diamine. The prepared ligands and their complexes have been characterized by elemental analyses, melting points, infrared spectroscopy and 'H NMR. The spectral data of the ligands and their complexes are discussed in relation to structural changes due to complications. In vitro cytotoxic study results show that the gold complexes exhibit moderate activity and block the proliferation of WHCOl cells with an IC50 range of 19.02 - 45.27μM, and IC50 range of 10.03 - 68.54μM for the WHCO6 lines.

Original languageEnglish
Title of host publicationWorld Congress on Engineering, WCE 2014
PublisherNewswood Limited
Pages637-640
Number of pages4
Volume2
ISBN (Electronic)9789881925374
ISBN (Print)9789881925350
Publication statusPublished - 2014
EventWorld Congress on Engineering and Computer Science 2014, WCECS 2014 - San Francisco, United States
Duration: Oct 22 2014Oct 24 2014

Other

OtherWorld Congress on Engineering and Computer Science 2014, WCECS 2014
CountryUnited States
CitySan Francisco
Period10/22/1410/24/14

Fingerprint

Gold
Ligands
Melting point
Condensation
Infrared spectroscopy
Nuclear magnetic resonance

All Science Journal Classification (ASJC) codes

  • Computer Science (miscellaneous)

Cite this

Chiririwa, H., & Muzenda, E. (2014). Synthesis, characterization of gold (III) complexes and an in vitro evaluation of their cytotoxic properties. In World Congress on Engineering, WCE 2014 (Vol. 2, pp. 637-640). Newswood Limited.
Chiririwa, Haleden ; Muzenda, Edison. / Synthesis, characterization of gold (III) complexes and an in vitro evaluation of their cytotoxic properties. World Congress on Engineering, WCE 2014. Vol. 2 Newswood Limited, 2014. pp. 637-640
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abstract = "Three tetradentate Schiff base ligands and gold (III) complexes have been synthesized by a 2:1 molar condensation of salicylaldehyde with ethylenediamine and o- phenylenediamine. The ligands are N,N'-bis (salicylaldehyde) ethylenediamine (1), N,N'-bis (salicylaldehyde) o- phenylenediamine (2) and N,N'-bis (salicylaldehyde)- dimethylbenzene-l,2-diamine. The prepared ligands and their complexes have been characterized by elemental analyses, melting points, infrared spectroscopy and 'H NMR. The spectral data of the ligands and their complexes are discussed in relation to structural changes due to complications. In vitro cytotoxic study results show that the gold complexes exhibit moderate activity and block the proliferation of WHCOl cells with an IC50 range of 19.02 - 45.27μM, and IC50 range of 10.03 - 68.54μM for the WHCO6 lines.",
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Chiririwa, H & Muzenda, E 2014, Synthesis, characterization of gold (III) complexes and an in vitro evaluation of their cytotoxic properties. in World Congress on Engineering, WCE 2014. vol. 2, Newswood Limited, pp. 637-640, World Congress on Engineering and Computer Science 2014, WCECS 2014, San Francisco, United States, 10/22/14.

Synthesis, characterization of gold (III) complexes and an in vitro evaluation of their cytotoxic properties. / Chiririwa, Haleden; Muzenda, Edison.

World Congress on Engineering, WCE 2014. Vol. 2 Newswood Limited, 2014. p. 637-640.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

TY - GEN

T1 - Synthesis, characterization of gold (III) complexes and an in vitro evaluation of their cytotoxic properties

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AU - Muzenda, Edison

PY - 2014

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N2 - Three tetradentate Schiff base ligands and gold (III) complexes have been synthesized by a 2:1 molar condensation of salicylaldehyde with ethylenediamine and o- phenylenediamine. The ligands are N,N'-bis (salicylaldehyde) ethylenediamine (1), N,N'-bis (salicylaldehyde) o- phenylenediamine (2) and N,N'-bis (salicylaldehyde)- dimethylbenzene-l,2-diamine. The prepared ligands and their complexes have been characterized by elemental analyses, melting points, infrared spectroscopy and 'H NMR. The spectral data of the ligands and their complexes are discussed in relation to structural changes due to complications. In vitro cytotoxic study results show that the gold complexes exhibit moderate activity and block the proliferation of WHCOl cells with an IC50 range of 19.02 - 45.27μM, and IC50 range of 10.03 - 68.54μM for the WHCO6 lines.

AB - Three tetradentate Schiff base ligands and gold (III) complexes have been synthesized by a 2:1 molar condensation of salicylaldehyde with ethylenediamine and o- phenylenediamine. The ligands are N,N'-bis (salicylaldehyde) ethylenediamine (1), N,N'-bis (salicylaldehyde) o- phenylenediamine (2) and N,N'-bis (salicylaldehyde)- dimethylbenzene-l,2-diamine. The prepared ligands and their complexes have been characterized by elemental analyses, melting points, infrared spectroscopy and 'H NMR. The spectral data of the ligands and their complexes are discussed in relation to structural changes due to complications. In vitro cytotoxic study results show that the gold complexes exhibit moderate activity and block the proliferation of WHCOl cells with an IC50 range of 19.02 - 45.27μM, and IC50 range of 10.03 - 68.54μM for the WHCO6 lines.

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Chiririwa H, Muzenda E. Synthesis, characterization of gold (III) complexes and an in vitro evaluation of their cytotoxic properties. In World Congress on Engineering, WCE 2014. Vol. 2. Newswood Limited. 2014. p. 637-640