Synthesis, antimicrobial, and brine shrimps lethality assays of 3,3-diaryl-4-(1-methyl-1H-indol-3-yl)azetidin-2-ones

Girija S. Singh, Yasser M.S.A. Al-Kahraman, Disah Mpadi, Masoom Yasinzai

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The paper describes the synthesis, characterization data, and biological activity (antibacterial, antifungal, and brine shrimps lethality) of new azetidin-2-ones. The compounds have been synthesized by the reaction of diarylketenes, generated in situ from thermal decomposition of the 2-diazo-1,2-diarylethanones, with N-(1-methyl-1H-indol-3-yl)methyleneamines. The compounds have been characterized by elemental analysis and spectral (IR, 1H and 13C NMR, and MS) data. The paper also reports the results of antibacterial, antifungal, and brine shrimps lethality assays of these compounds. Some of the compounds exhibited significant biological activity.

Original languageEnglish
Pages (from-to)614-619
Number of pages6
JournalJournal of Heterocyclic Chemistry
Volume52
Issue number2
DOIs
Publication statusPublished - Jan 1 2015

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Bioactivity
Assays
Pyrolysis
Nuclear magnetic resonance
Chemical analysis
brine
diazo-2

All Science Journal Classification (ASJC) codes

  • Organic Chemistry

Cite this

Singh, Girija S. ; Al-Kahraman, Yasser M.S.A. ; Mpadi, Disah ; Yasinzai, Masoom. / Synthesis, antimicrobial, and brine shrimps lethality assays of 3,3-diaryl-4-(1-methyl-1H-indol-3-yl)azetidin-2-ones. In: Journal of Heterocyclic Chemistry. 2015 ; Vol. 52, No. 2. pp. 614-619.
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Synthesis, antimicrobial, and brine shrimps lethality assays of 3,3-diaryl-4-(1-methyl-1H-indol-3-yl)azetidin-2-ones. / Singh, Girija S.; Al-Kahraman, Yasser M.S.A.; Mpadi, Disah; Yasinzai, Masoom.

In: Journal of Heterocyclic Chemistry, Vol. 52, No. 2, 01.01.2015, p. 614-619.

Research output: Contribution to journalArticle

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