A novel method was developed for the synthesis of highly pure strontium complexes in high yield. Syntheses proceeded along three pathways with optimum conditions being at T = 120-140°C, a base : acid ratio of 1.2 and 15 min reaction-time in an autoclave vessel. Large crystals were readily obtained within hours. The crystal structures of strontium R-glutamate hexahydrate (I) and strontium di(hydrogen S-glutamate) pentahydrate (II) were determined by X-ray powder diffraction methods at 295 K with Rietveld refinement (I: Space group P212121, Z = 4, a = 7.3519(2), b = 8.7616(2), c = 20.2627(5) Å; II: Space group P21, Z = 2, a = 8.7243(1), b = 7.2635(1), c = 14.6840(2) Å, β = 100.5414(7)°). Synthesis at room temperature provided four additional new strontium compounds that may be applicable as constituents of pharmaceutical products for the treatment of bone conditions.
All Science Journal Classification (ASJC) codes
- Physical and Theoretical Chemistry
- Materials Chemistry