Synthesis and characterisation of strontium carboxylates formed at room temperature and under hydrothermal conditions

Stephan Christgau, Kenny Ståhl, Jens E.T. Andersen

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

A novel method was developed for the synthesis of highly pure strontium complexes in high yield. Syntheses proceeded along three pathways with optimum conditions being at T = 120-140°C, a base : acid ratio of 1.2 and 15 min reaction-time in an autoclave vessel. Large crystals were readily obtained within hours. The crystal structures of strontium R-glutamate hexahydrate (I) and strontium di(hydrogen S-glutamate) pentahydrate (II) were determined by X-ray powder diffraction methods at 295 K with Rietveld refinement (I: Space group P212121, Z = 4, a = 7.3519(2), b = 8.7616(2), c = 20.2627(5) Å; II: Space group P21, Z = 2, a = 8.7243(1), b = 7.2635(1), c = 14.6840(2) Å, β = 100.5414(7)°). Synthesis at room temperature provided four additional new strontium compounds that may be applicable as constituents of pharmaceutical products for the treatment of bone conditions.

Original languageEnglish
Pages (from-to)2023-2030
Number of pages8
JournalJournal of Coordination Chemistry
Volume59
Issue number18
DOIs
Publication statusPublished - Dec 15 2006

Fingerprint

Strontium
strontium
carboxylates
glutamates
Strontium compounds
Glutamic Acid
strontium compounds
room temperature
synthesis
autoclaves
Rietveld refinement
Autoclaves
reaction time
X ray powder diffraction
Drug products
Temperature
bones
vessels
Hydrogen
Bone

All Science Journal Classification (ASJC) codes

  • Physical and Theoretical Chemistry
  • Materials Chemistry

Cite this

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abstract = "A novel method was developed for the synthesis of highly pure strontium complexes in high yield. Syntheses proceeded along three pathways with optimum conditions being at T = 120-140°C, a base : acid ratio of 1.2 and 15 min reaction-time in an autoclave vessel. Large crystals were readily obtained within hours. The crystal structures of strontium R-glutamate hexahydrate (I) and strontium di(hydrogen S-glutamate) pentahydrate (II) were determined by X-ray powder diffraction methods at 295 K with Rietveld refinement (I: Space group P212121, Z = 4, a = 7.3519(2), b = 8.7616(2), c = 20.2627(5) {\AA}; II: Space group P21, Z = 2, a = 8.7243(1), b = 7.2635(1), c = 14.6840(2) {\AA}, β = 100.5414(7)°). Synthesis at room temperature provided four additional new strontium compounds that may be applicable as constituents of pharmaceutical products for the treatment of bone conditions.",
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Synthesis and characterisation of strontium carboxylates formed at room temperature and under hydrothermal conditions. / Christgau, Stephan; Ståhl, Kenny; Andersen, Jens E.T.

In: Journal of Coordination Chemistry, Vol. 59, No. 18, 15.12.2006, p. 2023-2030.

Research output: Contribution to journalArticle

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AB - A novel method was developed for the synthesis of highly pure strontium complexes in high yield. Syntheses proceeded along three pathways with optimum conditions being at T = 120-140°C, a base : acid ratio of 1.2 and 15 min reaction-time in an autoclave vessel. Large crystals were readily obtained within hours. The crystal structures of strontium R-glutamate hexahydrate (I) and strontium di(hydrogen S-glutamate) pentahydrate (II) were determined by X-ray powder diffraction methods at 295 K with Rietveld refinement (I: Space group P212121, Z = 4, a = 7.3519(2), b = 8.7616(2), c = 20.2627(5) Å; II: Space group P21, Z = 2, a = 8.7243(1), b = 7.2635(1), c = 14.6840(2) Å, β = 100.5414(7)°). Synthesis at room temperature provided four additional new strontium compounds that may be applicable as constituents of pharmaceutical products for the treatment of bone conditions.

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