Protein-DNA interaction: Effect of helicity on bubble size

Conrad B. Tabi, Henri P Ekobena Fouda, Timoléon C. Kofané

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We study the nonlinear dynamics of the DNA double helical chain using a DNA-protein interaction spin-like model. The presence of helicity is taken into account and the dynamical equations are reduced to the completely integrable nonlinear Schrödinger equation. Helicity is shown to bring about highly localized and extended bubbles in the model. It is argued that these bubbles can be used to explain the open-states in DNA, under the action of RNA-polymerase, within the process of transcription.

Original languageEnglish
Pages (from-to)2220-2226
Number of pages7
JournalJournal of Computational and Theoretical Nanoscience
Volume8
Issue number11
DOIs
Publication statusPublished - Nov 2011

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Computational Mathematics
  • Electrical and Electronic Engineering

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