Protein-DNA interaction: Effect of helicity on bubble size

Conrad B. Tabi; Henri P Ekobena Fouda; Timoléon C. Kofané

doi:10.1166/jctn.2011.1948

Protein-DNA interaction: Effect of helicity on bubble size

Conrad B. Tabi, Henri P Ekobena Fouda, Timoléon C. Kofané

Physics & Astronomy

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

We study the nonlinear dynamics of the DNA double helical chain using a DNA-protein interaction spin-like model. The presence of helicity is taken into account and the dynamical equations are reduced to the completely integrable nonlinear Schrödinger equation. Helicity is shown to bring about highly localized and extended bubbles in the model. It is argued that these bubbles can be used to explain the open-states in DNA, under the action of RNA-polymerase, within the process of transcription.

Original language	English
Pages (from-to)	2220-2226
Number of pages	7
Journal	Journal of Computational and Theoretical Nanoscience
Volume	8
Issue number	11
DOIs	https://doi.org/10.1166/jctn.2011.1948
Publication status	Published - Nov 2011

All Science Journal Classification (ASJC) codes

Chemistry(all)
Materials Science(all)
Condensed Matter Physics
Computational Mathematics
Electrical and Electronic Engineering

Access to Document

10.1166/jctn.2011.1948

Cite this

@article{a7220f23afb94e4f8411a54b3a220a41,

title = "Protein-DNA interaction: Effect of helicity on bubble size",

abstract = "We study the nonlinear dynamics of the DNA double helical chain using a DNA-protein interaction spin-like model. The presence of helicity is taken into account and the dynamical equations are reduced to the completely integrable nonlinear Schr{\"o}dinger equation. Helicity is shown to bring about highly localized and extended bubbles in the model. It is argued that these bubbles can be used to explain the open-states in DNA, under the action of RNA-polymerase, within the process of transcription.",

author = "Tabi, {Conrad B.} and Fouda, {Henri P Ekobena} and Kofan{\'e}, {Timol{\'e}on C.}",

year = "2011",

month = nov,

doi = "10.1166/jctn.2011.1948",

language = "English",

volume = "8",

pages = "2220--2226",

journal = "Journal of Computational and Theoretical Nanoscience",

issn = "1546-1955",

publisher = "American Scientific Publishers",

number = "11",

}

TY - JOUR

T1 - Protein-DNA interaction

T2 - Effect of helicity on bubble size

AU - Tabi, Conrad B.

AU - Fouda, Henri P Ekobena

AU - Kofané, Timoléon C.

PY - 2011/11

Y1 - 2011/11

N2 - We study the nonlinear dynamics of the DNA double helical chain using a DNA-protein interaction spin-like model. The presence of helicity is taken into account and the dynamical equations are reduced to the completely integrable nonlinear Schrödinger equation. Helicity is shown to bring about highly localized and extended bubbles in the model. It is argued that these bubbles can be used to explain the open-states in DNA, under the action of RNA-polymerase, within the process of transcription.

AB - We study the nonlinear dynamics of the DNA double helical chain using a DNA-protein interaction spin-like model. The presence of helicity is taken into account and the dynamical equations are reduced to the completely integrable nonlinear Schrödinger equation. Helicity is shown to bring about highly localized and extended bubbles in the model. It is argued that these bubbles can be used to explain the open-states in DNA, under the action of RNA-polymerase, within the process of transcription.

UR - http://www.scopus.com/inward/record.url?scp=84856852840&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84856852840&partnerID=8YFLogxK

U2 - 10.1166/jctn.2011.1948

DO - 10.1166/jctn.2011.1948

M3 - Article

AN - SCOPUS:84856852840

SN - 1546-1955

VL - 8

SP - 2220

EP - 2226

JO - Journal of Computational and Theoretical Nanoscience

JF - Journal of Computational and Theoretical Nanoscience

IS - 11

ER -

Protein-DNA interaction: Effect of helicity on bubble size

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this