Protein-DNA interaction

Effect of helicity on bubble size

Conrad B. Tabi, Henri P Ekobena Fouda, Timoléon C. Kofané

    Research output: Contribution to journalArticle

    4 Citations (Scopus)

    Abstract

    We study the nonlinear dynamics of the DNA double helical chain using a DNA-protein interaction spin-like model. The presence of helicity is taken into account and the dynamical equations are reduced to the completely integrable nonlinear Schrödinger equation. Helicity is shown to bring about highly localized and extended bubbles in the model. It is argued that these bubbles can be used to explain the open-states in DNA, under the action of RNA-polymerase, within the process of transcription.

    Original languageEnglish
    Pages (from-to)2220-2226
    Number of pages7
    JournalJournal of Computational and Theoretical Nanoscience
    Volume8
    Issue number11
    DOIs
    Publication statusPublished - Nov 2011

    Fingerprint

    Interaction Effects
    Helicity
    Bubble
    DNA
    bubbles
    deoxyribonucleic acid
    proteins
    Proteins
    Protein
    Integrable Equation
    Transcription
    Nonlinear Dynamics
    Nonlinear Equations
    interactions
    DNA-Directed RNA Polymerases
    RNA
    Nonlinear equations
    nonlinear equations
    Interaction
    Model

    All Science Journal Classification (ASJC) codes

    • Chemistry(all)
    • Materials Science(all)
    • Condensed Matter Physics
    • Computational Mathematics
    • Electrical and Electronic Engineering

    Cite this

    Tabi, Conrad B. ; Fouda, Henri P Ekobena ; Kofané, Timoléon C. / Protein-DNA interaction : Effect of helicity on bubble size. In: Journal of Computational and Theoretical Nanoscience. 2011 ; Vol. 8, No. 11. pp. 2220-2226.
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    Protein-DNA interaction : Effect of helicity on bubble size. / Tabi, Conrad B.; Fouda, Henri P Ekobena; Kofané, Timoléon C.

    In: Journal of Computational and Theoretical Nanoscience, Vol. 8, No. 11, 11.2011, p. 2220-2226.

    Research output: Contribution to journalArticle

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    T2 - Effect of helicity on bubble size

    AU - Tabi, Conrad B.

    AU - Fouda, Henri P Ekobena

    AU - Kofané, Timoléon C.

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