Potentiometric and blood plasma simulation studies of nickel(ii) complexes of Poly(amino)amido pentadentate ligands: Computer aided metal-based drug design

Sebusi Odisitse, Graham E. Jackson

Research output: Contribution to journalArticle

Abstract

The thermodynamic equilibria of nickel(II) with N,N′-di(aminoethylene)-2,6-pyridinedicarbonylamine (L1), Bis-(N,N-dimethylethyl)-2,6-pyridinedicarboxamide (L2), and N,N′-bis[2(2-pyridyl)-methyl]pyridine-2,6-dicarboxamide (L3) have been studied at 25°C and an ionic strength of 0.15 mol dm-3 by glass electrode potentiometry. The protonation and formation constants added to blood plasma model predict that Cu(II) competes effectively against Ni(II), Zn(II), and Ca(II) for these ligands in vivo.

Original languageEnglish
Article number863612
JournalBioinorganic Chemistry and Applications
Volume2014
DOIs
Publication statusPublished - Jan 1 2014

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Plasma simulation
Potentiometry
Drug Design
Protonation
Ionic strength
Nickel
Thermodynamics
Osmolar Concentration
Glass
Electrodes
Blood
Metals
Ligands
Plasmas
Pharmaceutical Preparations
pyridine-2,6-dicarboxamide

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cite this

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AB - The thermodynamic equilibria of nickel(II) with N,N′-di(aminoethylene)-2,6-pyridinedicarbonylamine (L1), Bis-(N,N-dimethylethyl)-2,6-pyridinedicarboxamide (L2), and N,N′-bis[2(2-pyridyl)-methyl]pyridine-2,6-dicarboxamide (L3) have been studied at 25°C and an ionic strength of 0.15 mol dm-3 by glass electrode potentiometry. The protonation and formation constants added to blood plasma model predict that Cu(II) competes effectively against Ni(II), Zn(II), and Ca(II) for these ligands in vivo.

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