Abstract
The thermodynamic equilibria of nickel(II) with N,N′-di(aminoethylene)-2,6-pyridinedicarbonylamine (L1), Bis-(N,N-dimethylethyl)-2,6-pyridinedicarboxamide (L2), and N,N′-bis[2(2-pyridyl)-methyl]pyridine-2,6-dicarboxamide (L3) have been studied at 25°C and an ionic strength of 0.15 mol dm-3 by glass electrode potentiometry. The protonation and formation constants added to blood plasma model predict that Cu(II) competes effectively against Ni(II), Zn(II), and Ca(II) for these ligands in vivo.
| Original language | English |
|---|---|
| Article number | 863612 |
| Journal | Bioinorganic Chemistry and Applications |
| Volume | 2014 |
| DOIs | |
| Publication status | Published - Jan 1 2014 |
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All Science Journal Classification (ASJC) codes
- Biochemistry
- Organic Chemistry
- Inorganic Chemistry
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Potentiometric and blood plasma simulation studies of nickel(ii) complexes of Poly(amino)amido pentadentate ligands : Computer aided metal-based drug design. / Odisitse, Sebusi; Jackson, Graham E.
In: Bioinorganic Chemistry and Applications, Vol. 2014, 863612, 01.01.2014.Research output: Contribution to journal › Article
TY - JOUR
T1 - Potentiometric and blood plasma simulation studies of nickel(ii) complexes of Poly(amino)amido pentadentate ligands
T2 - Computer aided metal-based drug design
AU - Odisitse, Sebusi
AU - Jackson, Graham E.
PY - 2014/1/1
Y1 - 2014/1/1
N2 - The thermodynamic equilibria of nickel(II) with N,N′-di(aminoethylene)-2,6-pyridinedicarbonylamine (L1), Bis-(N,N-dimethylethyl)-2,6-pyridinedicarboxamide (L2), and N,N′-bis[2(2-pyridyl)-methyl]pyridine-2,6-dicarboxamide (L3) have been studied at 25°C and an ionic strength of 0.15 mol dm-3 by glass electrode potentiometry. The protonation and formation constants added to blood plasma model predict that Cu(II) competes effectively against Ni(II), Zn(II), and Ca(II) for these ligands in vivo.
AB - The thermodynamic equilibria of nickel(II) with N,N′-di(aminoethylene)-2,6-pyridinedicarbonylamine (L1), Bis-(N,N-dimethylethyl)-2,6-pyridinedicarboxamide (L2), and N,N′-bis[2(2-pyridyl)-methyl]pyridine-2,6-dicarboxamide (L3) have been studied at 25°C and an ionic strength of 0.15 mol dm-3 by glass electrode potentiometry. The protonation and formation constants added to blood plasma model predict that Cu(II) competes effectively against Ni(II), Zn(II), and Ca(II) for these ligands in vivo.
UR - http://www.scopus.com/inward/record.url?scp=84908344336&partnerID=8YFLogxK
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U2 - 10.1155/2014/863612
DO - 10.1155/2014/863612
M3 - Article
VL - 2014
JO - Bioinorganic Chemistry and Applications
JF - Bioinorganic Chemistry and Applications
SN - 1565-3633
M1 - 863612
ER -