Plant-made HIV vaccines and potential candidates

Jocelyne Trémouillaux-Guiller , Khaled Moustafa, Kathleen Hefferon, Goabaone Gaobotse, Abdullah Makhzoum

Research output: Contribution to journalReview article

Abstract

Millions of people around the world suffer from heavy social and health burdens related to HIV/AIDS and its associated opportunistic infections. To reduce these burdens, preventive and therapeutic vaccines are required. Effective HIV vaccines have been under investigation for several decades using different animal models. Potential plant-made HIV vaccine candidates have also gained attention in the past few years. In addition to this, broadly neutralizing antibodies produced in plants which can target conserved viral epitopes and neutralize mutating HIV strains have been identified. Numerous epitopes of glycoproteins and capsid proteins of HIV-1 are a part of HIV therapy. Here, we discuss some recent findings aiming to produce anti-HIV-1 recombinant proteins in engineered plants for AIDS prophylactics and therapeutic treatments.
Original languageEnglish
Pages (from-to)209-216
JournalCurrent Opinion in Biotechnology
Volume61
DOIs
Publication statusPublished - 2020

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AIDS Vaccines
Vaccines
Epitopes
HIV
HIV-1
Capsid Proteins
Acquired Immunodeficiency Syndrome
Neutralizing Antibodies
Recombinant Proteins
Recombinant proteins
Glycoproteins
Animals
Opportunistic Infections
Health
Antibodies
Therapeutics
Animal Models
Proteins

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Trémouillaux-Guiller , J., Moustafa, K., Hefferon, K., Gaobotse, G., & Makhzoum, A. (2020). Plant-made HIV vaccines and potential candidates. Current Opinion in Biotechnology, 61, 209-216. https://doi.org/10.1016/j.copbio.2020.01.004
Trémouillaux-Guiller , Jocelyne ; Moustafa, Khaled ; Hefferon, Kathleen ; Gaobotse, Goabaone ; Makhzoum, Abdullah. / Plant-made HIV vaccines and potential candidates. In: Current Opinion in Biotechnology. 2020 ; Vol. 61. pp. 209-216.
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Trémouillaux-Guiller , J, Moustafa, K, Hefferon, K, Gaobotse, G & Makhzoum, A 2020, 'Plant-made HIV vaccines and potential candidates', Current Opinion in Biotechnology, vol. 61, pp. 209-216. https://doi.org/10.1016/j.copbio.2020.01.004

Plant-made HIV vaccines and potential candidates. / Trémouillaux-Guiller , Jocelyne; Moustafa, Khaled; Hefferon, Kathleen; Gaobotse, Goabaone; Makhzoum, Abdullah.

In: Current Opinion in Biotechnology, Vol. 61, 2020, p. 209-216.

Research output: Contribution to journalReview article

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T1 - Plant-made HIV vaccines and potential candidates

AU - Trémouillaux-Guiller , Jocelyne

AU - Moustafa, Khaled

AU - Hefferon, Kathleen

AU - Gaobotse, Goabaone

AU - Makhzoum, Abdullah

PY - 2020

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AB - Millions of people around the world suffer from heavy social and health burdens related to HIV/AIDS and its associated opportunistic infections. To reduce these burdens, preventive and therapeutic vaccines are required. Effective HIV vaccines have been under investigation for several decades using different animal models. Potential plant-made HIV vaccine candidates have also gained attention in the past few years. In addition to this, broadly neutralizing antibodies produced in plants which can target conserved viral epitopes and neutralize mutating HIV strains have been identified. Numerous epitopes of glycoproteins and capsid proteins of HIV-1 are a part of HIV therapy. Here, we discuss some recent findings aiming to produce anti-HIV-1 recombinant proteins in engineered plants for AIDS prophylactics and therapeutic treatments.

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DO - 10.1016/j.copbio.2020.01.004

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