Planning and analysis of cross-over trials in infertility

Boikanyo Makubate, Stephen Senn

    Research output: Contribution to journalArticle

    12 Citations (Scopus)

    Abstract

    The use of cross-over trials in investigating treatments for infertility is discussed. A simple possible approach to analyzing such trials using the Mantel-Haenszel procedure is explained. A more flexible approach based on the normal-binomial mixture model of Ezzet and Whitehead is examined. It is shown how this may be implemented in various statistical packages by applying it to two real examples of trials in infertility. An approach that may be used to compare designs via simulation is explained briefly. It is concluded that provided that cross-over trials in infertility are regarded as parallel group trials with extra information rather than as cross-over trials with missing information, their use may be more promising than that has previously been concluded.

    Original languageEnglish
    Pages (from-to)3203-3210
    Number of pages8
    JournalStatistics in Medicine
    Volume29
    Issue number30
    DOIs
    Publication statusPublished - Dec 30 2010

    Fingerprint

    Crossover Trial
    Infertility
    Cross-Over Studies
    Planning
    Binomial Mixture
    Statistical package
    Normal Mixture
    Binomial Model
    Statistical Models
    Mixture Model
    Simulation

    All Science Journal Classification (ASJC) codes

    • Epidemiology
    • Statistics and Probability

    Cite this

    Makubate, Boikanyo ; Senn, Stephen. / Planning and analysis of cross-over trials in infertility. In: Statistics in Medicine. 2010 ; Vol. 29, No. 30. pp. 3203-3210.
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    Planning and analysis of cross-over trials in infertility. / Makubate, Boikanyo; Senn, Stephen.

    In: Statistics in Medicine, Vol. 29, No. 30, 30.12.2010, p. 3203-3210.

    Research output: Contribution to journalArticle

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