Planning and analysis of cross-over trials in infertility

Boikanyo Makubate, Stephen Senn

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The use of cross-over trials in investigating treatments for infertility is discussed. A simple possible approach to analyzing such trials using the Mantel-Haenszel procedure is explained. A more flexible approach based on the normal-binomial mixture model of Ezzet and Whitehead is examined. It is shown how this may be implemented in various statistical packages by applying it to two real examples of trials in infertility. An approach that may be used to compare designs via simulation is explained briefly. It is concluded that provided that cross-over trials in infertility are regarded as parallel group trials with extra information rather than as cross-over trials with missing information, their use may be more promising than that has previously been concluded.

Original languageEnglish
Pages (from-to)3203-3210
Number of pages8
JournalStatistics in Medicine
Volume29
Issue number30
DOIs
Publication statusPublished - Dec 30 2010

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Crossover Trial
Infertility
Cross-Over Studies
Planning
Binomial Mixture
Statistical package
Normal Mixture
Binomial Model
Statistical Models
Mixture Model
Simulation

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Statistics and Probability

Cite this

Makubate, Boikanyo ; Senn, Stephen. / Planning and analysis of cross-over trials in infertility. In: Statistics in Medicine. 2010 ; Vol. 29, No. 30. pp. 3203-3210.
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Planning and analysis of cross-over trials in infertility. / Makubate, Boikanyo; Senn, Stephen.

In: Statistics in Medicine, Vol. 29, No. 30, 30.12.2010, p. 3203-3210.

Research output: Contribution to journalArticle

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