Suitability of the solid desiccant cooling to supplement the conventional vapor compression refrigeration air conditioner has been studied for typical hot and humid climate. A solid desiccant and vapor compression hybrid air-conditioning system for a test room of cooling capacity 1.8 kW, has been modelled in simulation studio project and simulated in TRNSYS environment for the cooling season from March to September. The obtained results have been validated against experimental test data. The effects of ambient humidity ratio and temperature on coefficient of performance and supply air temperature have been evaluated. The variation in coefficient of performance has been obtained at various regeneration temperatures. The simulation results show the suitability of such systems for cooling of building in hot and humid climates. © 2015 Elsevier B.V. All rights reserved.