On the development of quality assurance

Research output: Contribution to journalReview article

11 Citations (Scopus)

Abstract

Contemporary research in quality assurance indicates that large uncertainties observed in interlaboratory comparisons to a large extent originate from a lack of competence of laboratory staff. This explanation is challenged by the present article for which six technologies and multiple series of experiments were investigated with respect to uncertainty of measurement and treatment of outliers. It was found that long-term precision was poor in comparison to short-term precision. The ratio of predicted uncertainty to observed uncertainty was determined as significantly above 1, and it was suggested that a correction factor is needed for the predicted uncertainty. This indicates that statistical control could be obtained only by treating many independent series of experiments and using pooled calibrations in the method validation. Retention of outliers in calculation of contents and calculation of uncertainties of certified reference materials (CRMs) gave results that differed significantly from those in the certificates of the CRMs.

Original languageEnglish
Pages (from-to)16-24
Number of pages9
JournalTrAC - Trends in Analytical Chemistry
Volume60
DOIs
Publication statusPublished - Sep 1 2014

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outlier
Quality assurance
interlaboratory comparison
experiment
calibration
quality assurance
calculation
material
Uncertainty
Experiments
Calibration
laboratory
comparison
method

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Environmental Chemistry
  • Spectroscopy

Cite this

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title = "On the development of quality assurance",
abstract = "Contemporary research in quality assurance indicates that large uncertainties observed in interlaboratory comparisons to a large extent originate from a lack of competence of laboratory staff. This explanation is challenged by the present article for which six technologies and multiple series of experiments were investigated with respect to uncertainty of measurement and treatment of outliers. It was found that long-term precision was poor in comparison to short-term precision. The ratio of predicted uncertainty to observed uncertainty was determined as significantly above 1, and it was suggested that a correction factor is needed for the predicted uncertainty. This indicates that statistical control could be obtained only by treating many independent series of experiments and using pooled calibrations in the method validation. Retention of outliers in calculation of contents and calculation of uncertainties of certified reference materials (CRMs) gave results that differed significantly from those in the certificates of the CRMs.",
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On the development of quality assurance. / Andersen, Jens E.T.

In: TrAC - Trends in Analytical Chemistry, Vol. 60, 01.09.2014, p. 16-24.

Research output: Contribution to journalReview article

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T1 - On the development of quality assurance

AU - Andersen, Jens E.T.

PY - 2014/9/1

Y1 - 2014/9/1

N2 - Contemporary research in quality assurance indicates that large uncertainties observed in interlaboratory comparisons to a large extent originate from a lack of competence of laboratory staff. This explanation is challenged by the present article for which six technologies and multiple series of experiments were investigated with respect to uncertainty of measurement and treatment of outliers. It was found that long-term precision was poor in comparison to short-term precision. The ratio of predicted uncertainty to observed uncertainty was determined as significantly above 1, and it was suggested that a correction factor is needed for the predicted uncertainty. This indicates that statistical control could be obtained only by treating many independent series of experiments and using pooled calibrations in the method validation. Retention of outliers in calculation of contents and calculation of uncertainties of certified reference materials (CRMs) gave results that differed significantly from those in the certificates of the CRMs.

AB - Contemporary research in quality assurance indicates that large uncertainties observed in interlaboratory comparisons to a large extent originate from a lack of competence of laboratory staff. This explanation is challenged by the present article for which six technologies and multiple series of experiments were investigated with respect to uncertainty of measurement and treatment of outliers. It was found that long-term precision was poor in comparison to short-term precision. The ratio of predicted uncertainty to observed uncertainty was determined as significantly above 1, and it was suggested that a correction factor is needed for the predicted uncertainty. This indicates that statistical control could be obtained only by treating many independent series of experiments and using pooled calibrations in the method validation. Retention of outliers in calculation of contents and calculation of uncertainties of certified reference materials (CRMs) gave results that differed significantly from those in the certificates of the CRMs.

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