Neuronal firing and DNA dynamics in a neural network

Armand Sylvin Etémé, Conrad B. Tabi, Jean Felix Beyala Ateba, Henri Paul Ekobena Fouda, T. C. Kofané

Research output: Contribution to journalArticle

Abstract

We study the mutual effects of neuronal electrical activity and DNA dynamics in a network of electrically coupled neurons with nearest neighbors communication. For that we develop by means of the coupling function method, a mathematical DNA-neuron model that can be considered as an extension of the simplified Hodgkin-Huxley models. Numerically, we explore the biological properties of the model with emphasis on local phase transitions and synchronous neural activity. Our results suggest that firing and coherent behavior of neural network are controlled by DNA dynamics. Conversely, neuronal activity induces DNA electrochemical denaturation. As a result, we expect that the prominent DNA-neuron model would be worth in controlling gene expression and neurodegen- erative diseases in the sensory thalamus.
Original languageEnglish
Article number125004
Pages (from-to)1-12
Number of pages12
JournalJournal of Physics Communications
Volume2
DOIs
Publication statusPublished - Dec 18 2018

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deoxyribonucleic acid
neurons
thalamus
biopolymer denaturation
gene expression
communication

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Etémé, A. S., Tabi, C. B., Beyala Ateba, J. F., Fouda, H. P. E., & Kofané, T. C. (2018). Neuronal firing and DNA dynamics in a neural network. Journal of Physics Communications, 2, 1-12. [125004]. https://doi.org/10.1088/2399-6528/aaf3f7
Etémé, Armand Sylvin ; Tabi, Conrad B. ; Beyala Ateba, Jean Felix ; Fouda, Henri Paul Ekobena ; Kofané, T. C. / Neuronal firing and DNA dynamics in a neural network. In: Journal of Physics Communications. 2018 ; Vol. 2. pp. 1-12.
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Etémé, AS, Tabi, CB, Beyala Ateba, JF, Fouda, HPE & Kofané, TC 2018, 'Neuronal firing and DNA dynamics in a neural network', Journal of Physics Communications, vol. 2, 125004, pp. 1-12. https://doi.org/10.1088/2399-6528/aaf3f7

Neuronal firing and DNA dynamics in a neural network. / Etémé, Armand Sylvin; Tabi, Conrad B.; Beyala Ateba, Jean Felix ; Fouda, Henri Paul Ekobena; Kofané, T. C.

In: Journal of Physics Communications, Vol. 2, 125004, 18.12.2018, p. 1-12.

Research output: Contribution to journalArticle

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AU - Kofané, T. C.

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