Abstract
A mathematical model is presented for predicting magnetic targeting of multifunctional carrier particles that deliver therapeutic agents to malignant tissue in vivo. These particles consist of a nonmagnetic core material that contains embedded magnetic nanoparticles and therapeutic agents such as photodynamic sensitizers. For in vivo therapy, the particles are injected into the micro vascular system upstream from malignant tissue, and captured at the tumor using an applied magnetic field. In this paper, a mathematical model is developed for predicting noninvasive magnetic targeting of therapeutic carrier particles in a micro vessel. The flow of blood in the micro vessel is described by a two phase Herschel- Bulkley fluid model. The Brinkmann model is used to characterize the permeable nature of the inner wall of the micro-vessel. The fluidic force on the carrier traversing the micro- vessel and the magnetic force due to the external magnetic field is taken into account. The model enables rapid parametric analysis of magnetic targeting as a function of key variables including the size of the carrier particle, the properties and volume fraction of the imbedded magnetic nanoparticles, the properties of the magnet, the micro vessel and the permeability of the micro vessel.
| Original language | English |
|---|---|
| Title of host publication | Biomedical and Biotechnology Engineering |
| Publisher | American Society of Mechanical Engineers (ASME) |
| Volume | 3 B |
| ISBN (Print) | 9780791856222 |
| DOIs | |
| Publication status | Published - 2013 |
| Event | ASME 2013 International Mechanical Engineering Congress and Exposition, IMECE 2013 - San Diego, CA, United States Duration: Nov 15 2013 → Nov 21 2013 |
Other
| Other | ASME 2013 International Mechanical Engineering Congress and Exposition, IMECE 2013 |
|---|---|
| Country | United States |
| City | San Diego, CA |
| Period | 11/15/13 → 11/21/13 |
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All Science Journal Classification (ASJC) codes
- Mechanical Engineering
Cite this
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Mathematical model on magnetic drug targeting in a permeable microvessel. / Shaw, S.; Sibanda, P.; Murthy, P. V S N.
Biomedical and Biotechnology Engineering. Vol. 3 B American Society of Mechanical Engineers (ASME), 2013.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
TY - GEN
T1 - Mathematical model on magnetic drug targeting in a permeable microvessel
AU - Shaw, S.
AU - Sibanda, P.
AU - Murthy, P. V S N
PY - 2013
Y1 - 2013
N2 - A mathematical model is presented for predicting magnetic targeting of multifunctional carrier particles that deliver therapeutic agents to malignant tissue in vivo. These particles consist of a nonmagnetic core material that contains embedded magnetic nanoparticles and therapeutic agents such as photodynamic sensitizers. For in vivo therapy, the particles are injected into the micro vascular system upstream from malignant tissue, and captured at the tumor using an applied magnetic field. In this paper, a mathematical model is developed for predicting noninvasive magnetic targeting of therapeutic carrier particles in a micro vessel. The flow of blood in the micro vessel is described by a two phase Herschel- Bulkley fluid model. The Brinkmann model is used to characterize the permeable nature of the inner wall of the micro-vessel. The fluidic force on the carrier traversing the micro- vessel and the magnetic force due to the external magnetic field is taken into account. The model enables rapid parametric analysis of magnetic targeting as a function of key variables including the size of the carrier particle, the properties and volume fraction of the imbedded magnetic nanoparticles, the properties of the magnet, the micro vessel and the permeability of the micro vessel.
AB - A mathematical model is presented for predicting magnetic targeting of multifunctional carrier particles that deliver therapeutic agents to malignant tissue in vivo. These particles consist of a nonmagnetic core material that contains embedded magnetic nanoparticles and therapeutic agents such as photodynamic sensitizers. For in vivo therapy, the particles are injected into the micro vascular system upstream from malignant tissue, and captured at the tumor using an applied magnetic field. In this paper, a mathematical model is developed for predicting noninvasive magnetic targeting of therapeutic carrier particles in a micro vessel. The flow of blood in the micro vessel is described by a two phase Herschel- Bulkley fluid model. The Brinkmann model is used to characterize the permeable nature of the inner wall of the micro-vessel. The fluidic force on the carrier traversing the micro- vessel and the magnetic force due to the external magnetic field is taken into account. The model enables rapid parametric analysis of magnetic targeting as a function of key variables including the size of the carrier particle, the properties and volume fraction of the imbedded magnetic nanoparticles, the properties of the magnet, the micro vessel and the permeability of the micro vessel.
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U2 - 10.1115/IMECE2013-66606
DO - 10.1115/IMECE2013-66606
M3 - Conference contribution
SN - 9780791856222
VL - 3 B
BT - Biomedical and Biotechnology Engineering
PB - American Society of Mechanical Engineers (ASME)
ER -