Human micro-vascular endothelial cell seeding on Cr-DLC thin films for mechanical heart valve applications

N. Ali, Y. Kousar, T. I. Okpalugo, V. Singh, M. Pease, A. A. Ogwu, J. Gracio, E. Titus, E. I. Meletis, M. J. Jackson

Research output: Contribution to journalArticlepeer-review

62 Citations (Scopus)

Abstract

In this investigation, chromium modified diamond-like-carbon (Cr-DLC) films were studied for potential applications in mechanical heart valves. Three Cr- DLC samples were prepared using a magnetron sputtering technique employing an intensified plasma assisted processing (IPAP) system. The three samples consisted of the following Cr content: 1 at.%, 5 at.% and 10 at.%. The biological response of human micro-vascular endothelial cells (HMV-EC) seeded on Cr-DLC films was evaluated in terms of initial cell attachment and growth. The Cr-DLC films were characterized using Raman spectroscopy, X-ray diffraction (XRD), scanning electron microscopy (SEM), secondary ion mass spectroscopy (SIMS) and by the contact angle technique. Endothelial cell adhesion and growth was found to be affected by changing the Cr content of Cr-DLC films.

Original languageEnglish
Pages (from-to)59-65
Number of pages7
JournalThin Solid Films
Volume515
Issue number1
DOIs
Publication statusPublished - Sep 25 2006
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Surfaces and Interfaces
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Fingerprint

Dive into the research topics of 'Human micro-vascular endothelial cell seeding on Cr-DLC thin films for mechanical heart valve applications'. Together they form a unique fingerprint.

Cite this