Highly Sensitive ZnO NWFET Biosensor Fabricated Using Top-Down Processes

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A highly sensitive low-doped ZnO nanowire field effect transistor (NWFET) biosensor has been fabricated and measured. The low doped biosensor with NWFET transducer was used to sense charge of the following substances: lysozyme (LYSO), phosphate buffered saline (PBS), bovine serum albumin (BSA). It achieved maximum sensitivity of -543.2 % for the PBS-LYSO protein and 13,069 % for the PBS-BSA protein. These results were achieved because the electrical measurement and characterisation was focused on the charge effect of the LYSO and BSA acting on the ZnO nanowire subthreshold region. The nano-fabrication process is stable and reproducible. The high sensitivity of the ZnO NWFET biosensor can be exploited for selective analyte detection by functionalizing the nanowire surface with antibodies and/or other biomolecular probe molecules.
Original languageEnglish
Pages (from-to)66-74
Number of pages9
JournalJournal of Nano Research
Volume55
DOIs
Publication statusPublished - Nov 2018

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Field effect transistors
bioinstrumentation
Biosensors
Nanowires
nanowires
field effect transistors
lysozyme
Muramidase
Bovine Serum Albumin
albumins
serums
phosphates
Phosphates
Enzymes
proteins
Proteins
nanofabrication
sensitivity
antibodies
Nanotechnology

Cite this

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title = "Highly Sensitive ZnO NWFET Biosensor Fabricated Using Top-Down Processes",
abstract = "A highly sensitive low-doped ZnO nanowire field effect transistor (NWFET) biosensor has been fabricated and measured. The low doped biosensor with NWFET transducer was used to sense charge of the following substances: lysozyme (LYSO), phosphate buffered saline (PBS), bovine serum albumin (BSA). It achieved maximum sensitivity of -543.2 {\%} for the PBS-LYSO protein and 13,069 {\%} for the PBS-BSA protein. These results were achieved because the electrical measurement and characterisation was focused on the charge effect of the LYSO and BSA acting on the ZnO nanowire subthreshold region. The nano-fabrication process is stable and reproducible. The high sensitivity of the ZnO NWFET biosensor can be exploited for selective analyte detection by functionalizing the nanowire surface with antibodies and/or other biomolecular probe molecules.",
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Highly Sensitive ZnO NWFET Biosensor Fabricated Using Top-Down Processes. / Ditshego, Nonofo M.J.

In: Journal of Nano Research, Vol. 55, 11.2018, p. 66-74.

Research output: Contribution to journalArticle

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AB - A highly sensitive low-doped ZnO nanowire field effect transistor (NWFET) biosensor has been fabricated and measured. The low doped biosensor with NWFET transducer was used to sense charge of the following substances: lysozyme (LYSO), phosphate buffered saline (PBS), bovine serum albumin (BSA). It achieved maximum sensitivity of -543.2 % for the PBS-LYSO protein and 13,069 % for the PBS-BSA protein. These results were achieved because the electrical measurement and characterisation was focused on the charge effect of the LYSO and BSA acting on the ZnO nanowire subthreshold region. The nano-fabrication process is stable and reproducible. The high sensitivity of the ZnO NWFET biosensor can be exploited for selective analyte detection by functionalizing the nanowire surface with antibodies and/or other biomolecular probe molecules.

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