Treatment of the 1,3,3-trisubstituted 4-[2′-(O-diarylacyl)- hydroxyphenyl]-2-azetidinones with sodium hydroxide in ethanol at room temperature lead to selective cleavage of the ester linkage in the substrates forming new 1,3,3-trisubstituted 4-(2′-hydroxyphenyl)-2-azetidinones, which have been characterized on the basis of analytical and spectral (IR, 1H and 13C NMR, MS) data. The structure elucidation also involves application of the HMQC and HMBC studies using 2-D NMR ( 1H-13C COSY) spectra. The antibacterial and antifungal activities of the products are reported.
|Number of pages||4|
|Journal||Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry|
|Publication status||Published - Jan 1 2008|
All Science Journal Classification (ASJC) codes
- Pharmacology, Toxicology and Pharmaceutics(all)
- Organic Chemistry