Fluoride accumulation and toxicity in laboratory populations of wild small mammals and white mice

Iain C. Boulton, John A. Cooke, Michael S. Johnson

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

A laboratory experiment was conducted to compare the toxicological response and metabolism of inorganic fluoride by three species of wild mammals and laboratory white mice (Mus musculus L.). The experimental populations of the wild species—the short‐tailed field vole (Microtus agrestis L.), the bank vole (Clethrionomys glareolus L.) and the wood mouse (Apodemus sylvaticus L.)—were laboratory reared from wild stock, and all test animals were exposed to 0, 40 or 80 μg F ml−1 in their drinking water for up to 84 days. The 40 and 80 μg F ml−1 treatments induced premature mortalities in M. agrestis and C. glareolus only. Differential intakes, absorption and retention of fluoride were evident between M. musculus and M. agrestis, the two species subject to cage studies of fluoride metabolism budgets. Interspecific variation in accumulation of fluoride with time was also evident between all four species as regards the femur, molars and incisors. Severe dental lesions were apparent in species surviving the 80 μg ml−1 treatment for 84 days. Overall, however, there were few clear differences in inherent species sensitivity to fluoride, the interspecific variation in metabolism and accumulation rates being attributable mainly to variation in intake.

Original languageEnglish
Pages (from-to)423-431
Number of pages9
JournalJournal of Applied Toxicology
Volume15
Issue number6
DOIs
Publication statusPublished - Jan 1 1995

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Mammals
Fluorides
Arvicolinae
Toxicity
Metabolism
Population
Murinae
Premature Mortality
Budgets
Incisor
Drinking Water
Femur
Toxicology
Wood
Tooth
Animals
Experiments

All Science Journal Classification (ASJC) codes

  • Toxicology

Cite this

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abstract = "A laboratory experiment was conducted to compare the toxicological response and metabolism of inorganic fluoride by three species of wild mammals and laboratory white mice (Mus musculus L.). The experimental populations of the wild species—the short‐tailed field vole (Microtus agrestis L.), the bank vole (Clethrionomys glareolus L.) and the wood mouse (Apodemus sylvaticus L.)—were laboratory reared from wild stock, and all test animals were exposed to 0, 40 or 80 μg F ml−1 in their drinking water for up to 84 days. The 40 and 80 μg F ml−1 treatments induced premature mortalities in M. agrestis and C. glareolus only. Differential intakes, absorption and retention of fluoride were evident between M. musculus and M. agrestis, the two species subject to cage studies of fluoride metabolism budgets. Interspecific variation in accumulation of fluoride with time was also evident between all four species as regards the femur, molars and incisors. Severe dental lesions were apparent in species surviving the 80 μg ml−1 treatment for 84 days. Overall, however, there were few clear differences in inherent species sensitivity to fluoride, the interspecific variation in metabolism and accumulation rates being attributable mainly to variation in intake.",
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Fluoride accumulation and toxicity in laboratory populations of wild small mammals and white mice. / Boulton, Iain C.; Cooke, John A.; Johnson, Michael S.

In: Journal of Applied Toxicology, Vol. 15, No. 6, 01.01.1995, p. 423-431.

Research output: Contribution to journalArticle

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