Epidemic modeling can be used to gain better understanding of infectious diseases, such as diarrhea. In the presented research, a continuous mathematical model has been formulated for diarrhea caused by salmonella. This model has been analyzed and simulated to be established in a functioning form. Elementary model analysis, such as working out the disease-free state and basic reproduction number, has been done for this model. The basic reproduction number has been calculated using the next generation matrix method. Stability analysis of the model has been done using the Routh-Hurwitz method. Sensitivity analysis and parameter estimation have been completed for the system too using MATLAB packages that work on the Latin Hypercube Sampling and Partial Rank Correlation Coefficient methods. It was established that as long as R0 < 1, there will be no epidemic. Upon simulation using assumed parameter values, the results produced comprehended the epidemic theory and practical situations. The system was proven stable using the Routh-Hurwitz criterion and parameter estimation was successfully completed. Salmonella diarrhea has been successfully modeled and analyzed in this research. This model has been flexibly built and it can be integrated onto certain platforms to be used as a predictive system to prevent further infections of salmonella diarrhea. © The Author(s) 2017.