Effects of the Cytotoxic T-Cells on the Dynamics of Co-Infection of HIV-1 and Mycobacterium tuberculosis

Chipo Mufudza, Senelani Musekwa, Edward Chiyaka

Research output: Contribution to journalArticle

Abstract

Enhancement of the Human Immunodeficiency Virus (HIV) specific cytotoxic T- cells mechanisms in an HIV-1 and Mycobacterium tuberculosis (Mtb) co-infected individual seems to improve the clinical picture of an individual by reducing Acquired Immuno Deficiency Syndrome (AIDS) state progression rate. In this paper, we develop a system of deterministic differential equations representing the immune cells involved in an HIV-1 and Mtb co-infected individual. Results show that although the non-lytic arm of the HIV-1 cytotoxic T-cells affects the co-infection dynamics more than the lytic factors, a combination of both factors results in a more positive reduced progression to the AIDS state. This is due to the increased protection of the CD4+ T-cells by the CTL mechanisms by further reducing infections and replications by the HIV. Thus, HIV-1 specific CTLs mechanisms’ involvement is here recommended to be part of a solution to the HIV and Mtb co-infection problems.
Original languageEnglish
Pages (from-to)191-212
Number of pages22
JournalJournal of Tuberculosis Research
Volume04
DOIs
Publication statusPublished - Jan 1 2016

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