Effects of replicative fitness on competing HIV strains

Faraimunashe Chirove, Edward M. Lungu

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We develop an n-strain model to show the effects of replicative fitness of competing viral strains exerting selective density-dependant infective pressure on each other. A two strain model is used to illustrate the results. A perturbation technique and numerical simulations were used to establish the existence and stability of steady states. More than one infected steady states governed by the replicative fitness resulted from the model exhibiting either strain replacement or co-infection. We found that the presence of two or more HIV strains could result in a disease-free state that, in general, is not globally stable.

Original languageEnglish
Pages (from-to)28-36
Number of pages9
JournalBioSystems
Volume113
Issue number1
DOIs
Publication statusPublished - Jul 1 2013

Fingerprint

Coinfection
Fitness
HIV
Pressure
Perturbation techniques
Perturbation Technique
Replacement
Infection
Model
Computer simulation
Numerical Simulation

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Applied Mathematics
  • Modelling and Simulation
  • Statistics and Probability

Cite this

Chirove, Faraimunashe ; Lungu, Edward M. / Effects of replicative fitness on competing HIV strains. In: BioSystems. 2013 ; Vol. 113, No. 1. pp. 28-36.
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Effects of replicative fitness on competing HIV strains. / Chirove, Faraimunashe; Lungu, Edward M.

In: BioSystems, Vol. 113, No. 1, 01.07.2013, p. 28-36.

Research output: Contribution to journalArticle

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