Effect of non-Newtonian characteristics of blood on magnetic targeting in the impermeable micro-vessel

Sachin Shaw, P. V.S.N. Murthy, S. C. Pradhan

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

In this investigation we consider to extended the work of Furlani and Furlani [15] by taking non-Newtonian fluid model for the blood in the impermeable micro-vessel. The behavior of blood is considered as the Herschel-Bulkley fluid which is more suitable for the micro-vessel of radius 50 μm. The expression for the fluidic force for the carrier particle traversing in the Herschel-Bulkley fluid is obtained first. Several factors that influence the magnetic targeting of the carrier particles in the microvasculature, such as the size of the carrier particle, the volume fraction of embedded magnetic nanoparticles, and the diameter of the micro-vessel are considered in the present problem. An algorithm is given to solve the system of coupled equations for trajectories of the carrier particle in the invasive case. The trajectories of the carrier particles are found in both invasive and noninvasive targeting systems. A comparison is make regarding the trajectories in these cases. Also, a prediction of the capture of therapeutic magnetic nanoparticle in the human microvasculature is made for different radii and volume fractions in both the invasive and noninvasive cases.

Original languageEnglish
Pages (from-to)1037-1043
Number of pages7
JournalJournal of Magnetism and Magnetic Materials
Volume322
Issue number8
DOIs
Publication statusPublished - Apr 1 2010

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics

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