Ecology and epidemiology of rabies in humans, domestic animals and wildlife in Namibia, 2011-2017

Emmanuel H. Hikufe, Conrad M. Freuling, Rauna Athingo, Albertina Shilongo, Emmy Else Ndevaetela, Maria Helao, Mathews Shiindi, Rainer Hassel, Alec Bishi, Siegfried Khaiseb, Juliet Kabajani, Jolandie van der Westhuizen, Gregorio Torres, Andrea Britton, Moetapele Letshwenyo, Karin Schwabenbauer, Thomas C. Mettenleiter, Nicolai Denzin, Susanne Amler, Franz J. ConrathsThomas Müller, Adrianatus Maseke

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Abstract

Rabies is a fatal zoonotic disease that causes a heavy burden on societies. Namibia, a country in southern Africa, is aiming at controlling the disease in its main reservoir, the domestic dog. To facilitate the implementation comprehensive information on the ecology and epidemiology of the disease and surveillance is of utmost importance. The study presented assesses the baseline data for both human and animal rabies surveillance in Namibia in recent times and establishes correlations with ecological and socio-economic data in order to provide an up-to-date picture on the epidemiology of rabies in Namibia. For instance, it was important to identify the main drivers in the epidemiology, and whether the control strategy by mass vaccination of dogs is undermined by cycles of rabies in wildlife. Rabies in humans was reported mainly from the Northern Communal Areas (NCAs), with a total of 113 cases from 2011 to 2017, representing an incidence of between 1.0 and 2.4 annual human rabies deaths per 100,000 inhabitants. Kavango, the region with the highest human rabies incidence was also the region with the lowest animal rabies surveillance intensity. Generally, the vast majority (77%) of dog samples originated from communal farm land, followed by urban areas (17%), while only a small fraction (3%) was submitted from freehold farm areas. In contrast, kudu and eland submissions were almost exclusively from freehold farmland (76%) and urban areas (19%), whereas the submission of cattle samples was evenly distributed among freehold farms (46%) and communal farm land (46%). Thelikelihood of sample submission decreased exponentially with distance to one of the two laboratories. Overall, 67% (N = 1,907) of all samples submitted tested rabies-positive, with the highest positivity rate observed in kudus (89%) and jackals (87%). The transmission cycle of rabies in dogs appears restricted to the northern communal areas of Namibia, whilst rabies in wildlife species is predominately reported from farmland in central Namibia, mostly affecting kudu (Tragelaphus strepsiceros) and livestock with a likely reservoir in wildlife canids such as jackals or bat-eared foxes. The analysis confirms the presence of two independent transmission cycles in Namibia with little geographic overlap, thus allowing for a sustainable control of rabies in dogs in the NCAs.

Original languageEnglish
Article numbere0007355
Number of pages19
JournalPLoS Neglected Tropical Diseases
Volume13
Issue number4
DOIs
Publication statusPublished - Apr 2019

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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    Hikufe, E. H., Freuling, C. M., Athingo, R., Shilongo, A., Ndevaetela, E. E., Helao, M., Shiindi, M., Hassel, R., Bishi, A., Khaiseb, S., Kabajani, J., van der Westhuizen, J., Torres, G., Britton, A., Letshwenyo, M., Schwabenbauer, K., Mettenleiter, T. C., Denzin, N., Amler, S., ... Maseke, A. (2019). Ecology and epidemiology of rabies in humans, domestic animals and wildlife in Namibia, 2011-2017. PLoS Neglected Tropical Diseases, 13(4), [e0007355]. https://doi.org/10.1371/journal.pntd.0007355