Dispersion characteristics of blood during nanoparticle assisted drug delivery process through a permeable microvessel

Sachin Shaw, Suvankar Ganguly, Precious Sibanda, Suman Chakraborty

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Nanoparticle assisted drug delivery holds considerable promise as a means of next generation of medicine that allows for the intravascular delivery of drugs and contrast agents. We analyze the dispersion characteristics of blood during a nanoparticle-assisted drug delivery process through a permeable microvessel. The contribution of molecular and convective diffusion is based on Taylor's theory of shear dispersion. The aggregation of red blood cells in blood flowing through small tubes (less than 40. μm) leads to the two-phase flow with a core of rouleaux surrounded by a cell-depleted peripheral layer. The core region models as a non-Newtonian Casson fluid and the peripheral region acts as a Newtonian fluid. We investigate the influence of the nanoparticle volume fraction, the permeability of the blood vessel, pressure distribution, yield stress and the radius of the nanoparticle on the effective dispersion. We show that the effective diffusion of the nanoparticles reduces with an increase in nanoparticle volume fraction. The permeability of the blood vessels increases the effective dispersion at the inlet. The present study contributes to the fundamental understanding on how the particulate nature of blood influences nanoparticle delivery, and is of particular significance in nanomedicine design for targeted drug delivery applications.

Original languageEnglish
Pages (from-to)25-33
Number of pages9
JournalMicrovascular Research
Volume92
DOIs
Publication statusPublished - Jan 1 2014

Fingerprint

Microvessels
Drug delivery
Nanoparticles
Blood
Pharmaceutical Preparations
Blood vessels
Blood Vessels
Permeability
Volume fraction
Nanomedicine
Medical nanotechnology
Fluids
Drug Design
Two phase flow
Pressure distribution
Contrast Media
Medicine
Yield stress
Agglomeration
Erythrocytes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Cardiology and Cardiovascular Medicine
  • Cell Biology

Cite this

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Dispersion characteristics of blood during nanoparticle assisted drug delivery process through a permeable microvessel. / Shaw, Sachin; Ganguly, Suvankar; Sibanda, Precious; Chakraborty, Suman.

In: Microvascular Research, Vol. 92, 01.01.2014, p. 25-33.

Research output: Contribution to journalArticle

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