Abstract
Formation constants of copper(ii), zinc(ii) and calcium(ii) with 3,5-diaminodiamido-4-oxahexacyclododecane (cageL) has been studied by glass electrode potentiometry at 25 °C and an ionic strength of 0.15 mol dm -3. Copper(ii) forms more stable complexes with cageL than zinc(ii) and calcium(ii). Metal ion complexation promotes deprotonation and coordination of the amide nitrogens resulting in overall tetragonal coordination of Cu 2+ suggested by the UV-visible electronic spectra. Speciation calculations using a blood plasma model suggest that zinc(ii) and calcium(ii) are good competitors of copper(ii) in vivo. Bio-distribution experiments using 64Cu-labelled Cu(ii)-cageL show that about 50% dose of the complex is retained in the body after 24 h.
| Original language | English |
|---|---|
| Pages (from-to) | 1140-1149 |
| Number of pages | 10 |
| Journal | Dalton Transactions |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - Jan 1 2007 |
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All Science Journal Classification (ASJC) codes
- Inorganic Chemistry
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Chemical speciation of copper(II) diaminediamide derivative of pentacycloundecane - A potential anti-inflammatory agent. / Odisitse, Sebusi; Jackson, Graham E.; Govender, Thavendran; Kruger, Hendrik G.; Singh, Amith.
In: Dalton Transactions, No. 11, 01.01.2007, p. 1140-1149.Research output: Contribution to journal › Article
TY - JOUR
T1 - Chemical speciation of copper(II) diaminediamide derivative of pentacycloundecane - A potential anti-inflammatory agent
AU - Odisitse, Sebusi
AU - Jackson, Graham E.
AU - Govender, Thavendran
AU - Kruger, Hendrik G.
AU - Singh, Amith
PY - 2007/1/1
Y1 - 2007/1/1
N2 - Formation constants of copper(ii), zinc(ii) and calcium(ii) with 3,5-diaminodiamido-4-oxahexacyclododecane (cageL) has been studied by glass electrode potentiometry at 25 °C and an ionic strength of 0.15 mol dm -3. Copper(ii) forms more stable complexes with cageL than zinc(ii) and calcium(ii). Metal ion complexation promotes deprotonation and coordination of the amide nitrogens resulting in overall tetragonal coordination of Cu 2+ suggested by the UV-visible electronic spectra. Speciation calculations using a blood plasma model suggest that zinc(ii) and calcium(ii) are good competitors of copper(ii) in vivo. Bio-distribution experiments using 64Cu-labelled Cu(ii)-cageL show that about 50% dose of the complex is retained in the body after 24 h.
AB - Formation constants of copper(ii), zinc(ii) and calcium(ii) with 3,5-diaminodiamido-4-oxahexacyclododecane (cageL) has been studied by glass electrode potentiometry at 25 °C and an ionic strength of 0.15 mol dm -3. Copper(ii) forms more stable complexes with cageL than zinc(ii) and calcium(ii). Metal ion complexation promotes deprotonation and coordination of the amide nitrogens resulting in overall tetragonal coordination of Cu 2+ suggested by the UV-visible electronic spectra. Speciation calculations using a blood plasma model suggest that zinc(ii) and calcium(ii) are good competitors of copper(ii) in vivo. Bio-distribution experiments using 64Cu-labelled Cu(ii)-cageL show that about 50% dose of the complex is retained in the body after 24 h.
UR - http://www.scopus.com/inward/record.url?scp=33847762492&partnerID=8YFLogxK
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U2 - 10.1039/b614878f
DO - 10.1039/b614878f
M3 - Article
SP - 1140
EP - 1149
JO - Dalton Transactions
JF - Dalton Transactions
SN - 1477-9226
IS - 11
ER -