Chemical speciation of copper(II) diaminediamide derivative of pentacycloundecane - A potential anti-inflammatory agent

Sebusi Odisitse, Graham E. Jackson, Thavendran Govender, Hendrik G. Kruger, Amith Singh

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Formation constants of copper(ii), zinc(ii) and calcium(ii) with 3,5-diaminodiamido-4-oxahexacyclododecane (cageL) has been studied by glass electrode potentiometry at 25 °C and an ionic strength of 0.15 mol dm -3. Copper(ii) forms more stable complexes with cageL than zinc(ii) and calcium(ii). Metal ion complexation promotes deprotonation and coordination of the amide nitrogens resulting in overall tetragonal coordination of Cu 2+ suggested by the UV-visible electronic spectra. Speciation calculations using a blood plasma model suggest that zinc(ii) and calcium(ii) are good competitors of copper(ii) in vivo. Bio-distribution experiments using 64Cu-labelled Cu(ii)-cageL show that about 50% dose of the complex is retained in the body after 24 h.

Original languageEnglish
Pages (from-to)1140-1149
Number of pages10
JournalDalton Transactions
Issue number11
Publication statusPublished - Jan 1 2007


All Science Journal Classification (ASJC) codes

  • Inorganic Chemistry

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