Can malaria parasite pathogenesis be prevented by treatment with tumor necrosis factor-alpha?

Avner Friedman, Edward M. Lungu

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

We consider a model incorporating the inuence of innate and adaptive immune responses on malaria pathogenesis. By calculating the model reproduction number for a special representation of cytokine interaction, we have shown that the cytokine tumour necrosis factorfican be administered to inhibit malaria infection. We have also found that if the cytokine F&z.ast; and a generic drug of effcacy are administered as dual therapy then clearance of the parasite can be achieved even for a generic drug of low effcacy. Our study is recommending administration of dual therapy as a strategy to prevent parasites from developing resistance to malaria treatment drugs.

Original languageEnglish
Pages (from-to)609-624
Number of pages16
JournalMathematical Biosciences and Engineering
Volume10
Issue number3
DOIs
Publication statusPublished - Jun 2013

Fingerprint

Tumor Necrosis Factor
Cytokines
Malaria
malaria
tumor necrosis factor-alpha
Generic Drugs
Drugs
Parasites
cytokines
pathogenesis
Tumor Necrosis Factor-alpha
parasites
Therapy
Drug therapy
Reproduction number
Necrosis
therapeutics
Immune Response
Adaptive Immunity
Clearance

All Science Journal Classification (ASJC) codes

  • Applied Mathematics
  • Modelling and Simulation
  • Computational Mathematics
  • Agricultural and Biological Sciences(all)
  • Medicine(all)

Cite this

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Can malaria parasite pathogenesis be prevented by treatment with tumor necrosis factor-alpha? / Friedman, Avner; Lungu, Edward M.

In: Mathematical Biosciences and Engineering, Vol. 10, No. 3, 06.2013, p. 609-624.

Research output: Contribution to journalArticle

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