Can malaria parasite pathogenesis be prevented by treatment with tumor necrosis factor-alpha?

Avner Friedman, Edward M. Lungu

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

We consider a model incorporating the inuence of innate and adaptive immune responses on malaria pathogenesis. By calculating the model reproduction number for a special representation of cytokine interaction, we have shown that the cytokine tumour necrosis factorfican be administered to inhibit malaria infection. We have also found that if the cytokine F&z.ast; and a generic drug of effcacy are administered as dual therapy then clearance of the parasite can be achieved even for a generic drug of low effcacy. Our study is recommending administration of dual therapy as a strategy to prevent parasites from developing resistance to malaria treatment drugs.

Original languageEnglish
Pages (from-to)609-624
Number of pages16
JournalMathematical Biosciences and Engineering
Volume10
Issue number3
DOIs
Publication statusPublished - Jun 2013

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All Science Journal Classification (ASJC) codes

  • Applied Mathematics
  • Modelling and Simulation
  • Computational Mathematics
  • Agricultural and Biological Sciences(all)
  • Medicine(all)

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