Can malaria parasite pathogenesis be prevented by treatment with tumor necrosis factor-alpha?

Avner Friedman, Edward M. Lungu

    Research output: Contribution to journalArticle

    1 Citation (Scopus)

    Abstract

    We consider a model incorporating the inuence of innate and adaptive immune responses on malaria pathogenesis. By calculating the model reproduction number for a special representation of cytokine interaction, we have shown that the cytokine tumour necrosis factorfican be administered to inhibit malaria infection. We have also found that if the cytokine F&z.ast; and a generic drug of effcacy are administered as dual therapy then clearance of the parasite can be achieved even for a generic drug of low effcacy. Our study is recommending administration of dual therapy as a strategy to prevent parasites from developing resistance to malaria treatment drugs.

    Original languageEnglish
    Pages (from-to)609-624
    Number of pages16
    JournalMathematical Biosciences and Engineering
    Volume10
    Issue number3
    DOIs
    Publication statusPublished - Jun 2013

    Fingerprint

    Tumor Necrosis Factor
    Cytokines
    Malaria
    malaria
    tumor necrosis factor-alpha
    Generic Drugs
    Drugs
    Parasites
    cytokines
    pathogenesis
    Tumor Necrosis Factor-alpha
    parasites
    Therapy
    Drug therapy
    Reproduction number
    Necrosis
    therapeutics
    Immune Response
    Adaptive Immunity
    Clearance

    All Science Journal Classification (ASJC) codes

    • Applied Mathematics
    • Modelling and Simulation
    • Computational Mathematics
    • Agricultural and Biological Sciences(all)
    • Medicine(all)

    Cite this

    @article{1aa8b77037a2404bba54207f04fce8ae,
    title = "Can malaria parasite pathogenesis be prevented by treatment with tumor necrosis factor-alpha?",
    abstract = "We consider a model incorporating the inuence of innate and adaptive immune responses on malaria pathogenesis. By calculating the model reproduction number for a special representation of cytokine interaction, we have shown that the cytokine tumour necrosis factorfican be administered to inhibit malaria infection. We have also found that if the cytokine F&z.ast; and a generic drug of effcacy are administered as dual therapy then clearance of the parasite can be achieved even for a generic drug of low effcacy. Our study is recommending administration of dual therapy as a strategy to prevent parasites from developing resistance to malaria treatment drugs.",
    author = "Avner Friedman and Lungu, {Edward M.}",
    year = "2013",
    month = "6",
    doi = "10.3934/mbe.2013.10.609",
    language = "English",
    volume = "10",
    pages = "609--624",
    journal = "Mathematical Biosciences and Engineering",
    issn = "1547-1063",
    publisher = "Arizona State University",
    number = "3",

    }

    Can malaria parasite pathogenesis be prevented by treatment with tumor necrosis factor-alpha? / Friedman, Avner; Lungu, Edward M.

    In: Mathematical Biosciences and Engineering, Vol. 10, No. 3, 06.2013, p. 609-624.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Can malaria parasite pathogenesis be prevented by treatment with tumor necrosis factor-alpha?

    AU - Friedman, Avner

    AU - Lungu, Edward M.

    PY - 2013/6

    Y1 - 2013/6

    N2 - We consider a model incorporating the inuence of innate and adaptive immune responses on malaria pathogenesis. By calculating the model reproduction number for a special representation of cytokine interaction, we have shown that the cytokine tumour necrosis factorfican be administered to inhibit malaria infection. We have also found that if the cytokine F&z.ast; and a generic drug of effcacy are administered as dual therapy then clearance of the parasite can be achieved even for a generic drug of low effcacy. Our study is recommending administration of dual therapy as a strategy to prevent parasites from developing resistance to malaria treatment drugs.

    AB - We consider a model incorporating the inuence of innate and adaptive immune responses on malaria pathogenesis. By calculating the model reproduction number for a special representation of cytokine interaction, we have shown that the cytokine tumour necrosis factorfican be administered to inhibit malaria infection. We have also found that if the cytokine F&z.ast; and a generic drug of effcacy are administered as dual therapy then clearance of the parasite can be achieved even for a generic drug of low effcacy. Our study is recommending administration of dual therapy as a strategy to prevent parasites from developing resistance to malaria treatment drugs.

    UR - http://www.scopus.com/inward/record.url?scp=84877044497&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=84877044497&partnerID=8YFLogxK

    U2 - 10.3934/mbe.2013.10.609

    DO - 10.3934/mbe.2013.10.609

    M3 - Article

    VL - 10

    SP - 609

    EP - 624

    JO - Mathematical Biosciences and Engineering

    JF - Mathematical Biosciences and Engineering

    SN - 1547-1063

    IS - 3

    ER -