Antimicrobial, crown gall tumor inhibitory and cytotoxicity assays of N-[(1-methyl-1H-indole-3-yl)methylene]amines synthesized by an improved protocol

Girija S. Singh, Yasser M.S.A. Al-Kahraman, Disah Mpadi, Masoom Yasinzai

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The present paper reports an easy preparation of imines of N-methyl-1H-indole-3-carboxaldehyde by its condensation with alkyl and aromatic amines in ethanol without using any catalyst or dehydrating agent. The compounds have been screened for their antibacterial, antifungal, crown gall tumor inhibitory, and cytotoxic activities. As a major finding some of the compounds exhibited potential biological activity. The imine containing a 4-chlorophenyl group exhibits potential antitumor activity and brine shrimp lethality against crown gall tumor and brine shrimps, respectively. Furthermore, this imine containing a 4-chlorophenyl group also exhibits significant antifungal activity against Candida albicans fungal strains. The compound containing N-diphenylmethyl group has been observed most active against the Gram-positive bacteria.

Original languageEnglish
Pages (from-to)382-387
Number of pages6
JournalMedicinal Chemistry
Volume10
Issue number4
DOIs
Publication statusPublished - Jan 1 2014

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Plant Tumors
Imines
Amines
Artemia
Neoplasms
Gram-Positive Bacteria
Candida albicans
Ethanol
1-methylindole

All Science Journal Classification (ASJC) codes

  • Drug Discovery

Cite this

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abstract = "The present paper reports an easy preparation of imines of N-methyl-1H-indole-3-carboxaldehyde by its condensation with alkyl and aromatic amines in ethanol without using any catalyst or dehydrating agent. The compounds have been screened for their antibacterial, antifungal, crown gall tumor inhibitory, and cytotoxic activities. As a major finding some of the compounds exhibited potential biological activity. The imine containing a 4-chlorophenyl group exhibits potential antitumor activity and brine shrimp lethality against crown gall tumor and brine shrimps, respectively. Furthermore, this imine containing a 4-chlorophenyl group also exhibits significant antifungal activity against Candida albicans fungal strains. The compound containing N-diphenylmethyl group has been observed most active against the Gram-positive bacteria.",
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Antimicrobial, crown gall tumor inhibitory and cytotoxicity assays of N-[(1-methyl-1H-indole-3-yl)methylene]amines synthesized by an improved protocol. / Singh, Girija S.; Al-Kahraman, Yasser M.S.A.; Mpadi, Disah; Yasinzai, Masoom.

In: Medicinal Chemistry, Vol. 10, No. 4, 01.01.2014, p. 382-387.

Research output: Contribution to journalArticle

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