Antibiotic resistance plasmids in wastewater treatment plants and their possible dissemination into the environment

Teddie O. Rahube, Christopher K. Yost

    Research output: Contribution to journalReview article

    24 Citations (Scopus)

    Abstract

    Antibiotic resistance plasmids found in wastewater treatment plants (WWTPs) may represent a threat to public health if they are readily disseminated into the environment and ultimately into pathogenic bacteria. The wastewater environments provide an ideal ecosystem for development and evolution of antibiotic resistance plasmids. Selective pressures for resistance to toxic compounds, high organic content and high bacterial diversity promotes gene exchange mechanisms involving interactions of conjugative plasmids with bacterial chromosomes, integrons and transposons resulting in the acquisition and accumulation of various antibiotic resistance genes into plasmids. Several studies have isolated plasmids from wastewater plants which carry resistance genes to almost all clinically relevant antibiotics. This review will discuss the possible release of these plasmids from WWTPs and their undesirable effects in the environment. Studies using advanced molecular detection tools and high throughput DNA sequencing technology help accurately quantify the prevalence and transmission of these plasmids in the environment. Ultimately assessing the significance of these plasmids as pollutants will help to determine the implications to public health.

    Original languageEnglish
    Pages (from-to)9183-9190
    Number of pages8
    JournalAfrican Journal of Biotechnology
    Volume9
    Issue number54
    Publication statusPublished - Dec 29 2010

    Fingerprint

    Microbial Drug Resistance
    Waste Water
    wastewater treatment
    antibiotic resistance
    plasmids
    Plasmids
    wastewater
    public health
    Public Health
    Bacterial Chromosomes
    Integrons
    Genes
    High-Throughput Nucleotide Sequencing
    genes
    Poisons
    toxic substances
    transposons
    Ecosystem
    pollutants
    antibiotics

    All Science Journal Classification (ASJC) codes

    • Agronomy and Crop Science
    • Biotechnology
    • Genetics
    • Molecular Biology
    • Applied Microbiology and Biotechnology

    Cite this

    @article{79d74605b1df480386fde4852c710909,
    title = "Antibiotic resistance plasmids in wastewater treatment plants and their possible dissemination into the environment",
    abstract = "Antibiotic resistance plasmids found in wastewater treatment plants (WWTPs) may represent a threat to public health if they are readily disseminated into the environment and ultimately into pathogenic bacteria. The wastewater environments provide an ideal ecosystem for development and evolution of antibiotic resistance plasmids. Selective pressures for resistance to toxic compounds, high organic content and high bacterial diversity promotes gene exchange mechanisms involving interactions of conjugative plasmids with bacterial chromosomes, integrons and transposons resulting in the acquisition and accumulation of various antibiotic resistance genes into plasmids. Several studies have isolated plasmids from wastewater plants which carry resistance genes to almost all clinically relevant antibiotics. This review will discuss the possible release of these plasmids from WWTPs and their undesirable effects in the environment. Studies using advanced molecular detection tools and high throughput DNA sequencing technology help accurately quantify the prevalence and transmission of these plasmids in the environment. Ultimately assessing the significance of these plasmids as pollutants will help to determine the implications to public health.",
    author = "Rahube, {Teddie O.} and Yost, {Christopher K.}",
    year = "2010",
    month = "12",
    day = "29",
    language = "English",
    volume = "9",
    pages = "9183--9190",
    journal = "African Journal of Biotechnology",
    issn = "1684-5315",
    publisher = "Academic Journals",
    number = "54",

    }

    Antibiotic resistance plasmids in wastewater treatment plants and their possible dissemination into the environment. / Rahube, Teddie O.; Yost, Christopher K.

    In: African Journal of Biotechnology, Vol. 9, No. 54, 29.12.2010, p. 9183-9190.

    Research output: Contribution to journalReview article

    TY - JOUR

    T1 - Antibiotic resistance plasmids in wastewater treatment plants and their possible dissemination into the environment

    AU - Rahube, Teddie O.

    AU - Yost, Christopher K.

    PY - 2010/12/29

    Y1 - 2010/12/29

    N2 - Antibiotic resistance plasmids found in wastewater treatment plants (WWTPs) may represent a threat to public health if they are readily disseminated into the environment and ultimately into pathogenic bacteria. The wastewater environments provide an ideal ecosystem for development and evolution of antibiotic resistance plasmids. Selective pressures for resistance to toxic compounds, high organic content and high bacterial diversity promotes gene exchange mechanisms involving interactions of conjugative plasmids with bacterial chromosomes, integrons and transposons resulting in the acquisition and accumulation of various antibiotic resistance genes into plasmids. Several studies have isolated plasmids from wastewater plants which carry resistance genes to almost all clinically relevant antibiotics. This review will discuss the possible release of these plasmids from WWTPs and their undesirable effects in the environment. Studies using advanced molecular detection tools and high throughput DNA sequencing technology help accurately quantify the prevalence and transmission of these plasmids in the environment. Ultimately assessing the significance of these plasmids as pollutants will help to determine the implications to public health.

    AB - Antibiotic resistance plasmids found in wastewater treatment plants (WWTPs) may represent a threat to public health if they are readily disseminated into the environment and ultimately into pathogenic bacteria. The wastewater environments provide an ideal ecosystem for development and evolution of antibiotic resistance plasmids. Selective pressures for resistance to toxic compounds, high organic content and high bacterial diversity promotes gene exchange mechanisms involving interactions of conjugative plasmids with bacterial chromosomes, integrons and transposons resulting in the acquisition and accumulation of various antibiotic resistance genes into plasmids. Several studies have isolated plasmids from wastewater plants which carry resistance genes to almost all clinically relevant antibiotics. This review will discuss the possible release of these plasmids from WWTPs and their undesirable effects in the environment. Studies using advanced molecular detection tools and high throughput DNA sequencing technology help accurately quantify the prevalence and transmission of these plasmids in the environment. Ultimately assessing the significance of these plasmids as pollutants will help to determine the implications to public health.

    UR - http://www.scopus.com/inward/record.url?scp=78651364955&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=78651364955&partnerID=8YFLogxK

    M3 - Review article

    VL - 9

    SP - 9183

    EP - 9190

    JO - African Journal of Biotechnology

    JF - African Journal of Biotechnology

    SN - 1684-5315

    IS - 54

    ER -