Antibiotic resistance plasmids in wastewater treatment plants and their possible dissemination into the environment

Teddie O. Rahube, Christopher K. Yost

Research output: Contribution to journalReview article

24 Citations (Scopus)

Abstract

Antibiotic resistance plasmids found in wastewater treatment plants (WWTPs) may represent a threat to public health if they are readily disseminated into the environment and ultimately into pathogenic bacteria. The wastewater environments provide an ideal ecosystem for development and evolution of antibiotic resistance plasmids. Selective pressures for resistance to toxic compounds, high organic content and high bacterial diversity promotes gene exchange mechanisms involving interactions of conjugative plasmids with bacterial chromosomes, integrons and transposons resulting in the acquisition and accumulation of various antibiotic resistance genes into plasmids. Several studies have isolated plasmids from wastewater plants which carry resistance genes to almost all clinically relevant antibiotics. This review will discuss the possible release of these plasmids from WWTPs and their undesirable effects in the environment. Studies using advanced molecular detection tools and high throughput DNA sequencing technology help accurately quantify the prevalence and transmission of these plasmids in the environment. Ultimately assessing the significance of these plasmids as pollutants will help to determine the implications to public health.

Original languageEnglish
Pages (from-to)9183-9190
Number of pages8
JournalAfrican Journal of Biotechnology
Volume9
Issue number54
Publication statusPublished - Dec 29 2010

Fingerprint

Microbial Drug Resistance
Waste Water
wastewater treatment
antibiotic resistance
plasmids
Plasmids
wastewater
public health
Public Health
Bacterial Chromosomes
Integrons
Genes
High-Throughput Nucleotide Sequencing
genes
Poisons
toxic substances
transposons
Ecosystem
pollutants
antibiotics

All Science Journal Classification (ASJC) codes

  • Agronomy and Crop Science
  • Biotechnology
  • Genetics
  • Molecular Biology
  • Applied Microbiology and Biotechnology

Cite this

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Antibiotic resistance plasmids in wastewater treatment plants and their possible dissemination into the environment. / Rahube, Teddie O.; Yost, Christopher K.

In: African Journal of Biotechnology, Vol. 9, No. 54, 29.12.2010, p. 9183-9190.

Research output: Contribution to journalReview article

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