Analysis of cyanide in blood by headspace-isotope-dilution-GC-MS

Lise Lotte Løbger, Henning Willads Petersen, J. E T Andersen

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

An uncomplicated, rapid, automated procedure for the analysis of low cyanide concentrations in whole blood is reported. The analysis was performed by headspace gas chromatography and mass spectrometry in the (1H12C14N) and m/z 29 (1H13C15N). Carryover from cyanide adsorption onto the surface of the needle was prevented by developing a new method that enabled automated flushing of the needle in between each cyanide analysis. Results were compared of ordinary calibrations and those of isotope dilutions. The total time of analysis was 18 min for a single cyanide analysis.

Original languageEnglish
Pages (from-to)2564-2586
Number of pages23
JournalAnalytical Letters
Volume41
Issue number14
DOIs
Publication statusPublished - Jan 1 2008

Fingerprint

Cyanides
Isotopes
Dilution
Blood
Needles
Gas chromatography
Gas Chromatography-Mass Spectrometry
Calibration
Adsorption
Mass spectrometry

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Clinical Biochemistry
  • Analytical Chemistry
  • Electrochemistry
  • Spectroscopy
  • Biochemistry, medical

Cite this

Løbger, Lise Lotte ; Petersen, Henning Willads ; Andersen, J. E T. / Analysis of cyanide in blood by headspace-isotope-dilution-GC-MS. In: Analytical Letters. 2008 ; Vol. 41, No. 14. pp. 2564-2586.
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Analysis of cyanide in blood by headspace-isotope-dilution-GC-MS. / Løbger, Lise Lotte; Petersen, Henning Willads; Andersen, J. E T.

In: Analytical Letters, Vol. 41, No. 14, 01.01.2008, p. 2564-2586.

Research output: Contribution to journalArticle

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