An efficient synthesis of flavans from salicylaldehyde and acetophenone derivatives

Ofentse Mazimba, Ishmael B. Masesane, Runner R. Majinda

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)

Abstract

An efficient total synthesis of flavans from the reactions of salicylaldehyde and acetophenone derivatives is reported. The synthesis involves preparation of chalcones through an aldol reaction followed by reduction of both the double bond and the ketone using NaBH4 and an acetic acid mediated cyclization. Methoxy groups on the aromatic rings did not affect significantly the yields of the procedure.
Original languageEnglish
Pages (from-to)6716-6718
Number of pages3
JournalTetrahedron Letters
Volume52
Issue number50
DOIs
Publication statusPublished - 2011

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