A Mathematical Model for the Treatment of Aids-Related Kaposi'S Sarcoma

Barbara Szomolay, Edward M. Lungu

Research output: Contribution to journalArticle

Abstract

We formulate a mathematical model to study the dynamics of HIV-1 related Kaposi's Sarcoma (KS) pathogenesis. KS progression is modeled as a dual process involving the primary infection of B cells, which sustains HHV-8 replication and the secondary infection of progenitor cells by HHV-8, which sustains the KS cell replication. We incorporate the pharmacodynamics of highly active antiretroviral therapy (HAART), or combination therapy (HAART plus KS therapy) and consider how each treatment strategy alters the disease progression. Our results indicate that administration of HAART to individuals co-infected with the HIV-1 and HHV-8 viruses can greatly amplify the therapeutic response of low-dose KS therapies. We have found that adherence levels above 85% can significantly reduce the risk of KS and HIV for a treatment periods under 1 year. For longer treatment periods, however, at least 90% adherence level is recommended.

Original languageEnglish
Pages (from-to)495-522
Number of pages28
JournalJournal of Biological Systems
Volume22
Issue number3
DOIs
Publication statusPublished - Sep 1 2014

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Pharmacodynamics
Kaposi's Sarcoma
sarcoma
Viruses
Therapy
Theoretical Models
mathematical models
Cells
Mathematical Model
Mathematical models
Human herpesvirus 8
therapeutics
Human Herpesvirus 8
human immunodeficiency virus
Highly Active Antiretroviral Therapy
Progression
Replication
Infection
Human immunodeficiency virus 1
Therapeutics

All Science Journal Classification (ASJC) codes

  • Ecology
  • Agricultural and Biological Sciences (miscellaneous)
  • Applied Mathematics

Cite this

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A Mathematical Model for the Treatment of Aids-Related Kaposi'S Sarcoma. / Szomolay, Barbara; Lungu, Edward M.

In: Journal of Biological Systems, Vol. 22, No. 3, 01.09.2014, p. 495-522.

Research output: Contribution to journalArticle

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